Recruiting

Observational Study

Sponsor:

Indiana University

Code:

NCT07340554

Conditions

Cannabis Use

Cannabis Dependence

Cannabis Use Disorder

Cannabis Abuse

Cannabis Intoxication

Eligibility Criteria

Sex: All

Age: 14 - 17

Healthy Volunteers: Not accepted

Interventions

Contingency Management

Elastic Net Regression

Study Details

Brief summary:

This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.

Conditions

Cannabis Use

Cannabis Dependence

Cannabis Use Disorder

Cannabis Abuse

Cannabis Intoxication

Study ID

NCT07340554

Start date

Jun 15, 2026

Status verified date

Jun, 2026

Completion date

May 1, 2030

Anticipated

Primary completion date

May 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 14-17 year old youth
  • Guardian 18 years or older
  • Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and/or hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant
  • Youth must endorse having used cannabis at least once per week over the past month OR youth must have been diagnosed with cannabis use disorder within the past three months

Exclusion Criteria:

  • Youth has a history of Fetal Alcohol Spectrum Disorder, intellectual disorders, pervasive development disorder or autism spectrum disorder, psychotic disorders, history of neurological problems (epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease) by parent/guardian report
  • Youth or caretaker who is monolingual non-English speaker
  • Youth who is currently experiencing active psychosis symptoms or suicidal/homicidal ideation or who has been hospitalized within the past 6 months for psychosis or suicidality/homicidality
  • Youth who is currently undergoing contingency management treatment for cannabis use disorder

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: Contingency Management and Elastic Net Regression

All participants will receive Contingency Management treatment for Cannabis Use.

An elastic net regression model will be applied to the neuroimaging data for all participants to estimate scores on the CUDIT.

Interventions

Contingency Management

Contingency management is an evidence-based behavioral intervention used to treat substance use disorders, including cannabis use disorder (CUD). Contingency management operates on the principles of instrumental learning, where positive reinforcement is used to encourage desired behaviors, such as abstinence from cannabis. First, specific target behaviors are identified for reinforcement. In CUD, this is often abstinence from cannabis use, verified through regular urine drug screens and self-reports. If the target behavior (i.e., abstaining from cannabis for a specified time period) is achieved, then patients receive tangible rewards immediately after attaining the target behavior. These rewards are often in the form of money, vouchers, or other incentives that are meaningful to the individual. We will examine whether success during contingency management treatment for cannabis use is associated with neural activity during instrumental learning in N=80 adolescents ages 14-17.

Elastic Net Regression

We will apply an elastic net regression model to the neuroimaging data to estimate CUDIT score based on neuroimaging data.

Primary outcome measure

  • Cannabis use frequency [ Time Frame: Screening and Post-Intervention Follow-Up Visit (2-4 weeks after last CM visit) ]
  • Cannabis Use Disorder Identification Test (CUDIT) Score [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Joseph Aloi, MD, PhD

317-278-5433liferaft@iu.edu

Katherine LeFevre, BS

317-278-5433liferaft@iu.edu

Locations

Indiana University School of Medicine

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Joseph Aloi, MD, PhD

317-278-5433liferaft@iu.edu

Katherine LeFevre, BS

317-278-5433liferaft@iu.edu

More Information

Sponsor

Indiana University

Last update posted

Jun 22, 2026

Last verified

Jun, 2026

Keywords

  • Cannabis
  • Marijuana
  • Addiction

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-04. This information was provided to ClinicalTrials.gov by Indiana University on 2026-06-22.