Recruiting
Phase 2

Sonrotoclax & Zanubrutinib

Sponsor:

Canadian Cancer Trials Group

Code:

NCT07341191

Conditions

Mantle Cell Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Zanubrutinib

Sonrotoclax

CAR-T Cell Therapy

Study Details

Brief summary:

The purpose of this study is to evaluate the effects of adding two oral medications (sonrotoclax plus zanubrutinib) to standard of care chimeric antigen receptor (CAR-T) cell therapy in participants with mantle cell lymphoma.

Conditions

Mantle Cell Lymphoma

Study ID

NCT07341191

Start date

Aug 24, 2026

Status verified date

Aug, 2026

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Have histologically confirmed mantle cell lymphoma that is relapsed or refractory after at least one prior line of systemic therapy
  • Eligible for and planned to receive Health Canada approved CAR-T.
  • Have a formalin fixed paraffin embedded tumour tissue block available and must have provided informed consent for the release of the block.
  • Presence of radiologically documented disease.
  • Measurable disease (one site bidimensionally measurable).
  • Age ≥ 18 years.
  • Have an ECOG performance status of 0, 1 or 2
  • Anticipated life expectancy of ≥ 6 months
  • Adequate hematologic and biochemical parameters
  • Must have received prior systemic therapy as shown below;
  • At least one line of systemic therapy including a Bruton's Tyrosine Kinase inhibitor (BTKi).
  • Participants who have previously received venetoclax, sonrotoclax, or any other BCL2 inhibitor (BCL2i) are eligible as long as progressive disease did not occur within 6 months of the last dose of BCL2i. Participants with progressive disease during BCL2i therapy or within 6 months of last dose are not eligible.
  • Participants must enter the study while on a BTKi or enroll to a substudy of the protocol to receive zanubrutinib for a minimum duration prior to enrolling to the main study.
  • Participants previously exposed to zanubrutinib are eligible irrespective of response to treatment.
  • Participants entering the study while on a BTKi must have their BTKi switched to zanubrutinib supplied through the study.
  • Participants must have recovered to ≤ grade 1 from all reversible toxicity related to prior therapies.
  • Adequate washout must be followed per protocol.
  • Prior high-dose myelosuppresive radiation is permitted ≥28 prior to enrollment.
  • Previous major surgery is permitted ≥28 days prior to enrollment. Participants of childbearing potential must have agreed to use a highly effective contraceptive method.

Exclusion Criteria

  • • Participants on active anticancer therapy for other advanced or metastatic malignancies.
  • Concurrent treatment with other anti-cancer therapy
  • Serious illnesses or medical conditions which would not permit the participant to be managed according to the protocol.
  • Known hypersensitivity to the study drug(s) or their components.
  • Prior CD19-directed CAR-T at any time, autologous hematopoietic cell transplantation within 6 weeks, or allogeneic hematopoietic cell transplantation within 3 months. Allogeneic hematopoietic cell transplantation recipients must be free of clinically-significant graft-versus-host disease (GvHD) and must be off immunosuppression for GvHD for at least 4 weeks before enrollment.
  • Untreated and/or uncontrolled cardiovascular conditions and/or symptomatic cardiac dysfunction (including cardiac ventricular arrhythmias requiring medication, history of 2nd or 3rd degree atrioventricular conduction defects) or unstable angina congestive heart failure or myocardial infarction within the previous year.
  • Active, uncontrolled bacterial, fungal, or viral infection within 14 days prior to enrollment
  • Pregnant or breastfeeding women.
  • Inability to discontinue use of moderate or strong CYP3A inducers or inhibitors during the ramp-up treatment period with sonrotoclax.
  • Live vaccination within 4 weeks prior to enrollment or who plan to receive a live vaccine during treatment or within 90 days post last dose.
  • Inability to swallow capsules or tablets or have any diseases significantly affecting GI function
  • Active central nervous system (CNS) disease; Participants with stable CNS disease are eligible.
  • Growth factors within 28 days prior to enrollment.

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Zanubrutinib + Sonrotoclax

Interventions

Zanubrutinib

assigned at enrollment

Sonrotoclax

assigned at enrollment

CAR-T Cell Therapy

Standard of Care

Primary outcome measure

  • Complete response post CAR-T [ Time Frame: 3.5 years ]

Central Contacts and Locations

Central contacts

Annette Hay

613-533-6430ahay@ctg.queensu.ca

Laura Pearce

613-533-6430lpearce@ctg.queensu.ca

Locations

BCCA - Vancouver

Recruiting

Vancouver, British Columbia, Canada, V5Z 4E6

Contacts

Diego Villa Restrepo

604 877-6000

University Health Network

Recruiting

Toronto, Ontario, Canada, M5G 2M9

More Information

Sponsor

Canadian Cancer Trials Group

Last update posted

Aug 26, 2026

Last verified

Aug, 2026

Keywords

  • CAR-T
  • Relapsed
  • Refractory
  • BTK inhibitor
  • BCL2 inhibitor

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Canadian Cancer Trials Group on 2026-08-26.