Recruiting

Observational Study

Sponsor:

Ohio State University Comprehensive Cancer Center

Code:

NCT07346092

Conditions

Tobacco-Related Carcinoma

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Interventions

Preventive Intervention

Preventive Intervention

Preventive Intervention

Survey Administration

Study Details

Brief summary:

This clinical trial studies the health perceptions and social behaviors of Ohio State University (OSU) graduate students to develop an interactive, social norms-based approach that is effective in communicating the addictive risks of oral nicotine pouches (ONPs). The use of ONPs is rising rapidly among young adults (YA). Various factors contribute to the growing popularity of ONPs, including their affordability, accessibility both online and in physical stores, discreet use, and heavy internet advertising. However, for those who are experimenting, have tried ONPs in the past, or have never used them but are surrounded by others who do, factors like affordability and availability may not be the only reasons for initiating or continuing use. Social norms are also a significant factor influencing YA tobacco use. Peer influence on college campuses and in other social environments may encourage YA to conform to behaviors they perceive as popular or acceptable. Being surrounded by peers who use ONPs may create pressure to try them, especially as YA seek to fit in within their social circles. Studying the health perceptions and social behaviors of OSU graduate students may help researchers develop an interactive, social norms-based approach that is effective in communicating the addictive risks of ONPs.

Conditions

Tobacco-Related Carcinoma

Study ID

NCT07346092

Start date

Mar 20, 2025

Status verified date

Mar, 2026

Completion date

Mar 20, 2027

Anticipated

Primary completion date

Mar 20, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • AIM 1: OSU graduate students aged 21 years or older
  • AIM 2 AND 3: Students identified in Aim 1 as susceptible to ONPs, having experimented with ONPs, or currently using ONPs-those considered at high risk for nicotine dependence-will be invited to participate in Aim 2 or Aim 3
  • AIM 3: Participants in Aim 2 will not be invited to participate in Aim 3, as they will have already been exposed to the experimental stimuli

Study Design

Enrollment

2000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

no intervention: Aim 1 (online survey)

Participants complete an online survey assessing ONP use patterns, perceptions of ONP-related norms, and interactions with ONP content on social media over 5-10 minutes on study.

experimental: Aim 2

Participants view four intervention messages shown in a randomized order. These messages are randomly selected from five message blocks, which are part of a total pool of 33 messages.

active comparator: Aim 3 condition I (static visual ONP risk messages)

Participants view static visual ONP risk messages on study.

experimental: Aim 3 condition II (dynamic visual ONP risk messages)

Participants view dynamic visual ONP risk messages on study.

Interventions

Preventive Intervention

View social norm-based ONP messages

Preventive Intervention

View static visual ONP risk messages

Preventive Intervention

View dynamic visual ONP risk messages

Survey Administration

Ancillary studies

Primary outcome measure

  • Susceptibility to Oral Nicotine Pouch Use (Three Item Susceptibility Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Perceived Harm of Oral Nicotine Pouches (Three Item Comparative Harm Perceptions of Oral Nicotine Pouches Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Descriptive Norm Perceptions of Oral Nicotine Pouch Use (Six Category Perceived Prevalence Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Injunctive Norm Perceptions of Oral Nicotine Pouch Use (Seven Point Approval Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Subjective Norm Perceptions of Oral Nicotine Pouch Use (Two Item Perceived Expectations Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Personal Norm Perceptions of Oral Nicotine Pouch Use (Four Item Personal Norms Scale) (Aim 1) [ Time Frame: Up to 2 years ]
  • Exposure to Oral Nicotine Pouch Information on Social Media (Self Report Communication Channel Checklist) (Aim 1) [ Time Frame: up to 2 years ]
  • Perceived Severity Regarding Oral Nicotine Pouch Use (Three Item Perceived Severity Scale) (Aim 1 & Aim 2) [ Time Frame: Up to 2 years ]
  • Self-Efficacy to Avoid Oral Nicotine Pouch Use (Self-Efficacy Scale) (Aim 2, Aim 3) [ Time Frame: Up to 2 years ]
  • Intention to Share Oral Nicotine Pouch Message on Social Media (Seven Item Sharing Intention Scale)(Aim 3) [ Time Frame: Up to 2 years ]
  • Attitudes Toward Oral Nicotine Pouches (Four Item Semantic Differential Attitude Scale) (Aim 3) [ Time Frame: up to 2 years ]

Central Contacts and Locations

Central contacts

The Ohio State University Comprehensive Cancer Center

1-800-293-5066OSUCCCClinicaltrials@osumc.edu

Locations

Ohio State University Comprehensive Cancer Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Megan E. Roberts, PhD

Roberts.1558@osu.edu

Principal Investigator:

Megan E. Roberts, PhD

More Information

Sponsor

Ohio State University Comprehensive Cancer Center

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University Comprehensive Cancer Center on 2026-03-05.