Recruiting
Phase 3

Eloralintide

Sponsor:

Eli Lilly and Company

Code:

NCT07353931

Conditions

Osteoarthritis

Overweight or Obesity

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Eloralintide

Placebo

Study Details

Brief summary:

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Conditions

Osteoarthritis

Overweight or Obesity

Study ID

NCT07353931

Start date

Feb 9, 2026

Status verified date

Aug, 2026

Completion date

May, 2028

Anticipated

Primary completion date

Mar, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
  • Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
  • Have tried at least once to lose weight through diet but were unsuccessful
  • Have osteoarthritis of the knee and at least one of the following conditions:

  • Be over 50 years old
  • Have morning knee stiffness that lasts about 30 minutes
  • Have a crackling or grinding sound or feeling in the knee

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • Have an active knee infection
  • Have had within 90 days prior to screening:

  • heart attack
  • stroke
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study Design

Enrollment

900 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Eloralintide (YOA1)

Participants will receive eloralintide subcutaneously (SC)

placebo comparator: Placebo (YOA1)

Participants will receive placebo SC

experimental: Eloralintide (YOA2)

Participants will receive eloralintide SC

placebo comparator: Placebo (YOA2)

Participants will receive placebo SC

Interventions

Eloralintide

Administered SC

Placebo

Placebo administered SC

Primary outcome measure

  • Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]
  • Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score [ Time Frame: Baseline, Week 64 ]

Central Contacts and Locations

Central contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

clinical_inquiry_hub@lilly.com

Locations

AMR Clinical

Recruiting

Mobile, Alabama, United States, 36608

Contacts

251-414-1984

Principal Investigator:

Harry Studdard

Care Access - 801 South Power Road, Mesa

Recruiting

Mesa, Arizona, United States, 85206

Contacts

877-791-0656

Principal Investigator:

Michael Waters

Elite Pain and Spine Institute - South Crimson Road

Recruiting

Mesa, Arizona, United States, 85209

Principal Investigator:

Zeeshan Malik

Elite Clinical Studies, LLC

Recruiting

Phoenix, Arizona, United States, 85018

Contacts

602-788-3437

Principal Investigator:

Joseph Lillo, DO

Tucson Orthopaedic Institute - North Wyatt Drive

Recruiting

Tucson, Arizona, United States, 85712

Contacts

520-404-0276

Principal Investigator:

Nebojsa Skrepnik

Ark Clinical Research - Fountain Valley

Recruiting

Fountain Valley, California, United States, 92708

Contacts

714-988-2021

Principal Investigator:

Mark Leibowitz

Wolverine Clinical Trials

Recruiting

Santa Ana, California, United States, 92706

Contacts

714-617-2426

Principal Investigator:

Behnam Khaleghi

Encompass Clinical Research

Recruiting

Spring Valley, California, United States, 91978

Contacts

619-660-9068

Principal Investigator:

Hanid Audish

Diablo Clinical Research, Inc.

Recruiting

Walnut Creek, California, United States, 94598

Contacts

925-930-7267

Principal Investigator:

Helen Stacey

Skylight Health Research - Colorado Springs

Recruiting

Colorado Springs, Colorado, United States, 80917

Principal Investigator:

Renee Flick

Westside Center for Clinical Research

Recruiting

Jacksonville, Florida, United States, 32205

Contacts

904-693-1490

Principal Investigator:

Matthew Braddock

Care Access - St. Petersburg

Recruiting

St. Petersburg, Florida, United States, 33710

Contacts

877-791-0656

Principal Investigator:

Gigi Lefebvre

Conquest Research

Recruiting

Winter Park, Florida, United States, 32789

Contacts

407-916-0060

Principal Investigator:

Anand Patel

Orita Clinical Research

Recruiting

Decatur, Georgia, United States, 30034

Principal Investigator:

Ahmad Jingo

Medical Research Partners

Recruiting

Ammon, Idaho, United States, 83406

Contacts

208-681-9070

Principal Investigator:

Joseph Moore

Great Lakes Clinical Trials - Ravenswood

Recruiting

Chicago, Illinois, United States, 60640

Contacts

773-275-3500

Principal Investigator:

Manish Jain

Qualmedica Research, LLC

Recruiting

Evansville, Indiana, United States, 47715

Contacts

812-205-2475

Principal Investigator:

Moges Sisay

AMR Clinical

Recruiting

Newton, Kansas, United States, 67114

Contacts

316-804-7304

Principal Investigator:

Troy Holdeman

Monroe Biomedical Research - Louisville

Recruiting

Louisville, Kentucky, United States, 40213

Contacts

502-515-5672

Principal Investigator:

Harold Bays

Skylight Health Research - Burlington

Recruiting

Burlington, Massachusetts, United States, 01803

Contacts

781-653-4281

Principal Investigator:

Timothy McAlindon

Care Access - Quincy

Recruiting

Quincy, Massachusetts, United States, 02169

Contacts

877-791-0656

Principal Investigator:

Chih Chao Yang

Ellipsis Research Group - Brooklyn - 7th Street

Recruiting

Brooklyn, New York, United States, 11215

Contacts

347-422-0317

Principal Investigator:

Jorge Serje

Rochester Clinical Research - Buffalo

Recruiting

Buffalo, New York, United States, 14127

Principal Investigator:

Rajiv Jain

NYC Research INC

Recruiting

Long Island City, New York, United States, 11106

Contacts

516-574-9232

Principal Investigator:

Anastasios Manessis

Rochester Clinical Research, LLC

Recruiting

Rochester, New York, United States, 14609

Contacts

585-288-0890

Principal Investigator:

Patrick Connors

Central States Research

Recruiting

Tulsa, Oklahoma, United States, 74136

Contacts

918-645-5400

Principal Investigator:

Sarah Land

Keystone Clinical Studies

Recruiting

Plymouth Meeting, Pennsylvania, United States, 19462

Principal Investigator:

Cameron Olezene

JCCT - Juno Bellaire Site

Recruiting

Bellaire, Texas, United States, 77401

Contacts

713-779-5494

Principal Investigator:

Rocio Harbison

Epic Medical Research - DeSoto

Recruiting

DeSoto, Texas, United States, 75115

Contacts

197-277-7695

Principal Investigator:

HARESH BOGHARA

Valley Institute of Research - Fort Worth

Recruiting

Fort Worth, Texas, United States, 76164

Contacts

817-625-7733

Principal Investigator:

Alex Guevara

Care Access - Houston

Recruiting

Houston, Texas, United States, 77054

Contacts

877-791-0656

Principal Investigator:

Ali Bajwa

VIP Trials

Recruiting

San Antonio, Texas, United States, 78230

Contacts

210-569-2672

Principal Investigator:

Juan Garza

Endeavor Clinical Trials

Recruiting

San Antonio, Texas, United States, 78240

Contacts

518-428-6859

Principal Investigator:

Nitendra Agarwal

Consano Clinical Research, LLC

Recruiting

Shavano Park, Texas, United States, 78231

Contacts

210-545-4900

Principal Investigator:

Michelle Welch

Texas Valley Clinical Research

Recruiting

Weslaco, Texas, United States, 78596

Contacts

956-431-8090

Principal Investigator:

Eduardo Luna

AMR Clinical

Recruiting

South Jordan, Utah, United States, 84095

Principal Investigator:

Curtis Andrews

Charlottesville Medical Research

Recruiting

Charlottesville, Virginia, United States, 22911

Contacts

434-817-2442

Principal Investigator:

James Clark

Paramount Clinical Research - Data Point Clinical Research

Recruiting

Kirkland, Washington, United States, 98034

Contacts

425-577-1107

Principal Investigator:

Javier Nazar

Apex Trials

Recruiting

Guelph, Canada, N1G 0B4

Contacts

519-341-3367

Principal Investigator:

Ken Woo

Diex Recherche Inc. Division Quebec

Recruiting

Québec, Canada, G1V 4T3

Contacts

5144773439

Principal Investigator:

Caroline Rheaume

Stouffville Medical Research Institute Inc.

Recruiting

Stouffville, Canada, L4A 1H2

Contacts

(905) 640-3100

Principal Investigator:

Nima Mirtorabi

Maple Leaf Research

Recruiting

Toronto, Canada, M5G 1K2

Principal Investigator:

Mona Loutfy

Dr. Anil K. Gupta Medicine Professional Corporation

Recruiting

Toronto, Canada, M9V 4B4

Contacts

6473442020

Principal Investigator:

Anil Gupta

Diex Recherche Inc. Division Victoriaville

Recruiting

Victoriaville, Canada, G6P 3Z8

Contacts

819-260-1172

Principal Investigator:

Eve Betit

More Information

Sponsor

Eli Lilly and Company

Last update posted

Aug 21, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Eli Lilly and Company on 2026-08-21.