Recruiting

TAE

Sponsor:

Université de Sherbrooke

Code:

NCT07360587

Conditions

Thyroid Nodules

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Thyroid Artery Embolization

Study Details

Brief summary:

Very few studies have investigated TAE as a treatment for goiter with compressive symptoms. What is the efficacy and safety of TAE for the treatment of compressive goiters in a population ineligible for or refusing standard therapy? This is a prospective interventional cohort study that will allow us to standardize imaging by improving quality data collection and fellow-up to assess the efficacy of TAE for compressive symptoms of nodular goiters. Not only to corroborate current emerging results but clearly define the expected results for this technique.

Conditions

Thyroid Nodules

Study ID

NCT07360587

Start date

Jan 31, 2026

Status verified date

Nov, 2025

Completion date

Dec 31, 2029

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient with compressive symptoms or significant tracheal or oesophageal compression at risk of causing symptoms attributed to a goiter AND
  • Ineligible for surgery/ablative treatments or preference for TAE over other treatments AND
  • TiRADS category 1, 2, 3 or 4 AND
  • Bethesda categories I or III on 2 different biopsies OR Bethesda II on one biopsy AND
  • Patient at least 18 years old.

Exclusion Criteria:

  • Comorbidities precluding endovascular procedure OR
  • TiRADS category 5 OR
  • Bethesda categories IV, V, VI on biopsy OR
  • Refusal of the patient to participate OR
  • Uncontrolled severe hyperthyroidism OR
  • Minor patient.

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Thyroid Artery Embolization

Patients with diagnosis of Goiter with compressive symptoms in which other alternatives lack or are refused by the patient himself.

Interventions

Thyroid Artery Embolization

Interruption of blood flow that supplies thyroid nodule using embolization technique.

Primary outcome measure

  • Change in Thyroid nodule volume [ Time Frame: Follow-ups at 1 week, and 3 months, 6 months and 12 months post-op. ]

Central Contacts and Locations

Central contacts

Laurent Fradet, MD FRCSC

+1-819-346-1110Laurent.Fradet@USherbrooke.ca

Locations

Centre Hospitalier Universitaire de Sherbrooke

Recruiting

Sherbrooke, Quebec, Canada, J1H5H3

Contacts

Laurent Fradet, MD FRCSC

1-819-346-1110Laurent.Fradet@USherbrooke.ca

Jaime Alberto Reina, BSc

1-819-346-1110jaime.alberto.reina.marino@usherbrooke.ca

More Information

Sponsor

Université de Sherbrooke

Last update posted

Jan 22, 2026

Last verified

Nov, 2025

Keywords

  • Goiter
  • Thyroid Artery Embolization
  • thyroid nodule

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Université de Sherbrooke on 2026-01-22.