Recruiting

Brain Health PRO

Sponsor:

University of British Columbia

Code:

NCT07364019

Conditions

Dementia Prevention

Subjective Cognitive Impairment

Mild Cognitive Impairment

Cognitive Change

Lifestyle Intervention

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Brain Health PRO

Brain Health PRO

Study Details

Brief summary:

This study will recruit participants at risk for dementia to participate in an online educational program called Brain Health PRO (BHPro). The BHPro intervention is designed to address modifiable risk factors for dementia through a 6-month, fully online, educational program conveying the best available evidence for lifestyle changes that can mitigate dementia risk, and foster engagement toward one's own brain health. Achieving lifestyle changes in a diverse Canadian population through online education would be a major achievement in dementia prevention in Canada, with widespread personal and socioeconomic benefits.

Eligible participants will be randomly assigned to either start Brain Health PRO immediately or in 6 months (delayed-start control group). All participants will have the opportunity to have access to BHPro for 6 months during the course of the study and will have open access to all content for 12 months following the initial 6-month intervention. Participation will last from 18-24 months depending on group assignment.

Conditions

Dementia Prevention

Subjective Cognitive Impairment

Mild Cognitive Impairment

Cognitive Change

Lifestyle Intervention

Study ID

NCT07364019

Start date

May 7, 2026

Status verified date

May, 2026

Completion date

Dec 31, 2028

Anticipated

Primary completion date

Dec 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Completion and documentation of the electronic Informed Consent Process (from the participant)
  • Sufficient proficiency in English or French to undergo online assessments and participate in an online educational program.
  • Technical ability to participate in an online educational program and remote assessments (i.e., regularly have access to a computer or tablet with an internet connection; have access to a desktop or laptop computer with an internet connection at least once every 6 months; ability to send and receive emails; ability to complete online assessments)
  • Sufficient vision to participate in an online educational program and complete online cognitive testing
  • Ages 50-80
  • Classified as being at increased risk of dementia based on at least one of the following:

  • First-degree family history of dementia
  • Education level at or below high school (grade 12 or less)
  • Self-Reported: Hypertension, Hypercholesterolemia, Body Mass Index > 30 kg/m2 (derived from NIH Metric BMI Calculator), or Physical Inactivity (active is defined as engaging in a minimum of 20- 30 min of physical activity causing sweating and breathlessness, at least 2 times a week)

Exclusion Criteria:

  • Individuals who have a clinical diagnosis of Dementia (based on self-report)
  • Individuals who are currently participating in or have participated in a past study involving BHPro

Study Design

Enrollment

700 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Immediate BHPro Intervention Group

Participants in this group will start Brain Health PRO immediately at baseline

other: Delayed Start BHPro

Participants in this group will start Brain Health PRO in 6 months (delayed)

Interventions

Brain Health PRO

Immediate start of 6-month Brain Health PRO Intervention

Brain Health PRO

Delayed start of 6-month Brain Health PRO

Primary outcome measure

  • Change in modifiable risk factors as measured by a 7-item composite dementia risk factor score after 6 months. [ Time Frame: Change from baseline to month 6 ]

Central Contacts and Locations

Central contacts

Pennny Slack, MSc

604-822-6379penny.slack@ubc.ca

Locations

University of British Colubmia

Recruiting

Vancouver, British Columbia, Canada, V6T 1Z3

Contacts

Penny Slack, MSc

604-822-6379penny.slack@ubc.ca

Principal Investigator:

Haakon Nygaard, MD, PhD

More Information

Sponsor

University of British Columbia

Last update posted

May 19, 2026

Last verified

May, 2026

Keywords

  • dementia education
  • at risk for dementia
  • lifestyle intervention
  • dementia reduction
  • dementia risk factor
  • dementia prevention
  • cognitive impairment
  • Alzheimer risk

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2026-05-19.