Recruiting

Potato & Beef

Sponsor:

University of Illinois at Urbana-Champaign

Code:

NCT07367854

Conditions

Muscle Protein Synthetic Response to Protein

Muscle Protein Synthesis

Muscle Health

Protein Metabolism

Recreational Activities

Eligibility Criteria

Sex: All

Age: 19 - 40

Healthy Volunteers: Accepted

Interventions

Resistance Exercise

Potato and Beef

Bread and Beef

Beef

Study Details

Brief summary:

In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat/7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.

Conditions

Muscle Protein Synthetic Response to Protein

Muscle Protein Synthesis

Muscle Health

Protein Metabolism

Recreational Activities

Study ID

NCT07367854

Start date

Mar 1, 2026

Status verified date

Mar, 2026

Completion date

Nov 1, 2028

Anticipated

Primary completion date

Oct 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 19-40 yrs
  • Pre-menopausal
  • Recreationally-active
  • Weight stable for prior 6 months

Exclusion Criteria:

  • Age outside of range (20 - 35 yrs)
  • Pregnancy
  • Irregular menstrual cycles (i.e., \~21 day or \~35 day cycle)
  • Participation in previous research using L-\[1-13C\] leucine and L-\[ring-2H5\] phenylalanine
  • Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)

Study Design

Enrollment

15 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Potato and Beef (PB)

Participants will ingest 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 37 g carbohydrate, 5 g fat, 4 g fiber) after resistance exercise.

experimental: Bread and Beef (BB)

Participants will ingest 2 slices white bread and 2 ounce-equivalent lean ground beef combination (262 kcals, 19.8 g protein, 28 g carbohydrate, 6.8 g fat, 1.8 g fiber) after resistance exercise.

experimental: Beef (B)

Participants will ingest 2 ounce-equivalent lean ground beef (110 kcals, 14.8 g protein, 5 g fat) after resistance exercise.

Interventions

Resistance Exercise

Participants will perform leg press and leg extension immediately prior to ingestion of either potato-beef combination, bread-beef combination, or beef alone.

Potato and Beef

Participants will ingest baked russet potato and cooked ground beef immediately after resistance exercise.

Bread and Beef

Participants will ingest white bread and cooked ground beef immediately after resistance exercise.

Beef

Participants will ingest cooked ground beef immediately after resistance exercise.

Primary outcome measure

  • Myofibrillar protein fractional synthesis rate [ Time Frame: Baseline muscle biopsy (-150 minutes), Postabsorptive muscle biopsy (-30 minutes), and Postprandial muscle biopsy (300 minutes) ]
  • Whole body leucine kinetics [ Time Frame: Breath sample collection time points: -210, -150, -90, -60, -30, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, and 300 minutes. ]

Central Contacts and Locations

Central contacts

Nicholas A Burd (Full Professor), PhD

2172440970naburd@illinois.edu

Calvin Chen, PhD Student

2173906655cw148@illinois.edu

Locations

Louise Freer Hall

Recruiting

Urbana, Illinois, United States, 61801

Contacts

Calvin Wei-Ting Chen

2173906655cw148@illinois.edu

Principal Investigator:

Nicholas A. Burd, PhD

More Information

Sponsor

University of Illinois at Urbana-Champaign

Last update posted

May 1, 2026

Last verified

Mar, 2026

Keywords

  • protein
  • leucine kinetics
  • food matrix
  • protein synthesis
  • potato
  • stable isotope tracers
  • constant infusions
  • food combinations

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Illinois at Urbana-Champaign on 2026-05-01.