Recruiting

Costoclavicular BlockMinimal Effective Volume 90% for Double-injection Costoclavicular Block

Sponsor:

McGill University Health Centre/Research Institute of the McGill University Health Centre

Code:

NCT07374952

Conditions

Brachial Plexus Blocks

Lidocaine

Nerve Block

Dose Finding Study

Costoclavicular Block

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Interventions

Ultrasound-guided double-injection costoclavicular nerve block with same previous volume

Ultrasound-guided double-injection costoclavicular nerve block with lower volume

Study Details

Brief summary:

In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block.

This study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve.

Block dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD).

The double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord).

The ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.

Conditions

Brachial Plexus Blocks

Lidocaine

Nerve Block

Dose Finding Study

Costoclavicular Block

Study ID

NCT07374952

Start date

Jun 16, 2026

Status verified date

Jul, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Inclusion Criteria:

Age between 18 and 70 years
American Society of Anesthesiologists classification 1-3
Body mass index between 20 and 30

Exclusion Criteria:

Adults who are unable to give their own consent
Pre-existing neuropathy (assessed by history and physical examination)
Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)
Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)
Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)
Allergy to LA
Pregnancy
Prior surgery in the infraclavicular region
Chronic pain syndromes requiring opioid intake at home

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Sequential

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

active comparator: Costoclavicular block with same previous successful volume

Patients randomized to this group will receive the same volume that was successful in the previous recruitment.

experimental: Costoclavicular block with lower volume

This group will be randomized to receive a fixed lower volume than the previously successful block.

Interventions

Ultrasound-guided double-injection costoclavicular nerve block with same previous volume

ultrasound-guided double-injection costoclavicular nerve block with the same volume used in the previous successful block

Ultrasound-guided double-injection costoclavicular nerve block with lower volume

Ultrasound-guided double-injection costoclavicular nerve block with lower volume than the previous successful block

Primary outcome measure

Success rate [ Time Frame: 30 minutes ]

Central Contacts and Locations

Central contacts

Julián Aliste, M.D.

+15149341934-43795 julian.aliste@mcgill.ca

Locations

Montreal General Hospital

Recruiting

Montreal, Quebec, Canada, H3G 1A4

Contacts

Julián Aliste, MD

5149341934 julian.aliste@mcgill.ca

More Information

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Last update posted

Jul 7, 2026

Last verified

Jul, 2026

Keywords

costoclavicular block
double injection technique
dose finding
nerve block
lidocaine

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre on 2026-07-07.