Recruiting

High-load vs. Low-load

Sponsor:

University of Miami

Code:

NCT07378813

Conditions

Activity, Motor

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Interventions

Low-Load Resistance Training

High-Load Resistance Training

Study Details

Brief summary:

This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Conditions

Activity, Motor

Study ID

NCT07378813

Start date

Jan 30, 2026

Status verified date

Jan, 2026

Completion date

May 30, 2027

Anticipated

Primary completion date

May 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Parkinson's Disease Hoehn \& Yahr Stages 1-3
  • Able to walk 50m unassisted
  • Able to understand and communicate in English
  • A Montreal Cognitive Assessment (MoCA) score above 18

Exclusion Criteria:

  • Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
  • Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
  • Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Low-Load Resistance Training

Participants will receive low-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

active comparator: High-Load Resistance Training

Participants will receive high-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Interventions

Low-Load Resistance Training

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.

High-Load Resistance Training

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using four sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.

Primary outcome measure

  • Change in neuromuscular performance as measured by 1-repetition maximum (1RM) [ Time Frame: [Time Frame: Baseline, 12 weeks] ]
  • Change in neuromuscular performance as measured by Power Production [ Time Frame: Baseline, 12 weeks ]

Central Contacts and Locations

Central contacts

Ethan J Elway, MS

3052844173exe453@miami.edu

Joseph F. Signorile, PhD

3052843105jsignorile@miami.edu

Locations

Laboratory of Neruomuscular Research and Active Aging

Recruiting

Coral Gables, Florida, United States, 33147

Contacts

Ethan Elway, MS

305-284-4173exe453@miami.edu

Joseph F. Signorile, PhD

3052843105JSIGNORILE@MIAMI.EDU

Principal Investigator:

Joseph F. Signorile, PhD

More Information

Sponsor

University of Miami

Last update posted

Feb 2, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Miami on 2026-02-02.