Recruiting

Meditation Practices

Sponsor:

UCLA

Code:

NCT07386769

Conditions

People Who Use Opioids/People With Opioid Use Disorder (OUD)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Meditation

Psychoeducation

Study Details

Brief summary:

The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with opioid-related outcomes.

Conditions

People Who Use Opioids/People With Opioid Use Disorder (OUD)

Study ID

NCT07386769

Start date

Feb 2, 2026

Status verified date

Jan, 2026

Completion date

May, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Persons, aged 18 or older
2. Current near daily use of prescribed or illicit opioid agonists or mixed opioid agonist-antagonists for ≥90 days
3. Must be able to speak and understand English

Exclusion Criteria:

1. Cognitive Impairment that would preclude participation in the research protocol
2. Active suicidal intent or psychosis

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Meditation

20 minutes of guided meditation during the laboratory session involving mindfulness of breathing and lovingkindness practice.

active comparator: Psychoeducation

Psychoeducation about opioid neuropharmacology.

Interventions

Meditation

20 minutes of guided meditation during the laboratory session involving mindfulness of breathing and lovingkindness practice.

Psychoeducation

20 minute psychoeducational script on the impact of opioid use on the brain.

Primary outcome measure

  • Neurophysiological synchrony [ Time Frame: During the intervention and for 5 minutes afterwards ]

Central Contacts and Locations

Central contacts

Lori Kroh, BS

619-259-0735l1kroh@health.ucsd.edu

Kelly Hendrickson, MS

kehendrickson@health.ucsd.edu

Locations

University of California, San Diego

Recruiting

La Jolla, California, United States, 92093

Contacts

Eric Garland, PhD

858-822-4092egarland@health.ucsd.edu

More Information

Sponsor

University of California, San Diego

Last update posted

Feb 4, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2026-02-04.