Recruiting

ECO, EXCAP, MAAT

Sponsor:

University of Rochester

Code:

NCT07390045

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Not accepted

Interventions

EXCAP

MAAT

ECO

Study Details

Brief summary:

The objective of this study is to assess the preliminary effects of an integrated exercise and cognitive rehabilitation intervention (ECO), an exercise intervention (EXCAP), and a cognitive rehabilitation intervention (MAAT) as compared to usual care on objective cognition (Trail Making Test).

Conditions

Cancer

Study ID

NCT07390045

Start date

Jul 31, 2026

Status verified date

Jul, 2026

Completion date

Mar 31, 2028

Anticipated

Primary completion date

Mar 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Not accepted

Inclusion criteria:

  • Age ≥65 years (from date of consent, confirmed on the electronic medical record)
  • A diagnosis of any cancer
  • Have completed curative intent treatments

  • Patients on endocrine therapies are allowed to enroll
  • Patients with hematologic malignancies after autologous or allogeneic stem cell transplant are allowed to enroll if they have completed curative-intent treatment
  • Answered "yes" to the verbal question "Do you have concerns about memory or other thinking abilities following your cancer treatment?"
  • Able to speak English (interventions are available in English only)
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0-3#
  • No medical contraindications to exercise#
  • Able to walk 4 meters#
  • Able to provide informed consent#

  • Confirmed through eligibility confirmation with the patient's oncologist or their designee

Exclusion criteria:

  • Any physical, psychological, or social impairments that would interfere with a patient's ability to participate in the study as determined by the patient's oncologist or their designee
  • Unwilling to complete study procedures

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Exercise for Cancer Patients (EXCAP; Intervention)

Exercise for Cancer Patients (EXCAP) is an individually tailored, low-to-moderate intensity, home-based walking and progressive resistance exercise program designed for patients with cancer delivered by an exercise physiologist. It also includes digital health applications, allowing the tracking of exercise adherence, barriers to exercise, and symptoms.

experimental: Memory and Attention Adaptation Training (MAAT; Intervention)

Memory and Attention Adaptation Training (MAAT) is an intervention based on cognitive behavioral therapy principles that integrates cognitive rehabilitation skills and provides education and training in adaptive behavioral coping skills, stress management techniques, and compensation strategies to address CRCD.

no intervention: Usual Care

Patients in the control group will receive care as usual.

experimental: Exercise and Cognition (ECO; Intervention)

Patients will receive the integrated EXCAP and MAAT interventions.

Interventions

EXCAP

The first component of the EXCAP exercise program is an individually tailored walking prescription and provides low to moderately intense aerobic exercise \[5-8 exercise rating of perceived exertion on the American College of Sports Medicine (ACSM) revised rating scale, which is a visual analog scale ranging from 1 = "Not tired at all" to 10 = "So tired, I can't go anymore"\] 7 days a week. This walking prescription will be developed and individually tailored for each patient based on step data reported by the patient. A Garmin activity tracker (a wearable sensor-based device) will be used to record the number of steps they walk daily during the 4-7 day baseline assessment. Patients will report their steps daily on a paper form, electronically via REDCap, or over the phone to the study staff at the end of the 4-7 day baseline assessment period. Alternatively, steps can also be obtained via the activity tracker by study staff.

MAAT

The MAAT intervention consists of 10 manualized workshops that will be delivered by a trained clinician. Patients will be provided with a workbook for skills practice in between sessions. A summary of workshop content is provided in Table 1.

During Workshop #2, study staff or a trained clinician will provide patients with a link to a Vimeo video through the app. The Vimeo video has been created by the study team and guides patients through relaxation strategies to use before stressful events. Patients will be able to access the video without providing any personal information to the website.

ECO

Patients will receive the integrated EXCAP and MAAT interventions.

Primary outcome measure

  • Objective cognition [ Time Frame: Change from baseline to week 12 ]

Central Contacts and Locations

Central contacts

Kah Poh Loh

585-276-4353Kahpoh_Loh@URMC.Rochester.edu

Becky Gravenstede

585-727-4728becky_gravenstede@urmc.rochester.edu

Locations

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Kah Poh Loh

585-276-4353Kahpoh_Loh@URMC.Rochester.edu

More Information

Sponsor

University of Rochester

Last update posted

Jul 6, 2026

Last verified

Jul, 2026

Keywords

  • geriatric oncology
  • cancer survivors
  • exercise
  • cognitive rehabilitation
  • cognition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Rochester on 2026-07-06.