Recruiting
Phase 3

Eloralintide

Sponsor:

Eli Lilly and Company

Code:

NCT07392190

Conditions

Overweight

Obesity

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Eloralintide

Placebo

Study Details

Brief summary:

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy.

Participation in the study will last about 80 weeks.

Conditions

Overweight

Obesity

Study ID

NCT07392190

Start date

Feb 10, 2026

Status verified date

Aug, 2026

Completion date

Jul, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Are on stable incretin therapy at screening
  • With persistent obesity or overweight defined as:

  • ≥30 kg/m2 OR
  • ≥27 kg/m2 with at least one existing obesity related complication at screening:

  • hypertension
  • dyslipidemia
  • obstructive sleep apnea
  • cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
  • type 2 diabetes
  • Have a stable body weight (<5% body weight change) at screening

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes
  • Have taken any of the following antihyperglycemic medications within 90 days before screening:

  • dipeptidyl peptidase-4 (DPP-4) inhibitors
  • amylin analogs
  • insulin
  • Have had within 90 days prior to screening:

  • heart attack
  • stroke
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

Study Design

Enrollment

900 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Eloralintide Dose 1

Participants will receive eloralintide subcutaneously (SC)

experimental: Eloralintide Dose 2

Participants will receive eloralintide SC

experimental: Eloralintide Dose 3

Participants will receive eloralintide SC

experimental: Eloralintide Dose 4

Participants will receive eloralintide SC

placebo comparator: Placebo

Participants will receive placebo SC

Interventions

Eloralintide

Administered SC

Placebo

Administered SC

Primary outcome measure

  • Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]

Central Contacts and Locations

Central contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

clinical_inquiry_hub@lilly.com

Locations

Birmingham Clinical Research

Recruiting

Birmingham, Alabama, United States, 35209

Contacts

205-870-4343

Principal Investigator:

Nova Law

RIO Clinical Trials - Phoenix

Recruiting

Phoenix, Arizona, United States, 85016

Contacts

480-966-7882

Principal Investigator:

Kenneth Steil

Headlands Research - Scottsdale

Recruiting

Scottsdale, Arizona, United States, 85260

Contacts

480-725-8708

Principal Investigator:

Benjamin Clark

Novak Clinical Research - Tucson - North La Cholla Boulevard

Recruiting

Tucson, Arizona, United States, 85741

Principal Investigator:

Thili Kulatilake

Irvine Clinical Research

Recruiting

Irvine, California, United States, 92614

Contacts

949-753-1663

Principal Investigator:

Elly Lee

Scripps Whittier Diabetes Institute

Recruiting

La Jolla, California, United States, 92037

Contacts

858-824-5352

Principal Investigator:

Athena Philis-Tsimikas

Peninsula Research Associates

Recruiting

Rolling Hills Estates, California, United States, 90274

Contacts

310-265-1623

Principal Investigator:

Lawrence Sher

Care Access - Sacramento

Recruiting

Sacramento, California, United States, 95831

Contacts

925-734-2331

Principal Investigator:

Francisco Garcia

Artemis Institute for Clinical Research

Recruiting

San Diego, California, United States, 92123

Contacts

858-278-3647

Principal Investigator:

Stacey Layle

Southern California Clinical Research

Recruiting

Santa Ana, California, United States, 92701

Contacts

714-474-2173

Principal Investigator:

Wayne Ho

University Clinical Investigators, Inc.

Recruiting

Tustin, California, United States, 92780

Contacts

714-734-7944

Principal Investigator:

Joanna Van

New England Research Associates, LLC

Recruiting

Bridgeport, Connecticut, United States, 06606

Contacts

203-374-9816

Principal Investigator:

Ilja Hulinsky

Yale University School of Medicine

Recruiting

New Haven, Connecticut, United States, 06519

Contacts

203-785-7421

Principal Investigator:

Ania Jastreboff

Chase Medical Research, LLC

Recruiting

Waterbury, Connecticut, United States, 06708

Contacts

203-419-4420

Principal Investigator:

Joseph Soufer

JEM Research Institute

Recruiting

Atlantis, Florida, United States, 33462

Contacts

561-968-2933

Principal Investigator:

David Halpert

AMR Clinical

Recruiting

Doral, Florida, United States, 33172

Principal Investigator:

Abid Chaudhry

Northeast Research Institute (NERI)

Recruiting

Fleming Island, Florida, United States, 32003

Contacts

904-541-8225

Principal Investigator:

Senan Sultan

Jacksonville Center for Clinical Research

Recruiting

Jacksonville, Florida, United States, 32216

Contacts

904-730-0101

Principal Investigator:

Alpa Patel

New Horizon Research Center

Recruiting

Miami, Florida, United States, 33165

Contacts

305-226-3933

Principal Investigator:

Lazaro Nunez

St Johns Center for Clinical Research

Recruiting

Saint Augustine, Florida, United States, 32086

Contacts

904-209-0043

Principal Investigator:

Ameeth Vedre

Metabolic Research Institute, Inc.

Recruiting

West Palm Beach, Florida, United States, 33401

Contacts

561-802-3060

Principal Investigator:

Barry Horowitz, MD

Teak Research Consults - Dunwoody

Recruiting

Dunwoody, Georgia, United States, 30338

Contacts

470-403-4755

Principal Investigator:

Aakar Thaker

Center for Advanced Research & Education

Recruiting

Gainesville, Georgia, United States, 30501

Contacts

770-534-5154

Principal Investigator:

Angela Ritter

Clinical Research Atlanta

Recruiting

Stockbridge, Georgia, United States, 30281

Contacts

770-507-6867

Principal Investigator:

Jason Agran

Family First Medical Center

Recruiting

Idaho Falls, Idaho, United States, 83404

Contacts

208-552-7700

Principal Investigator:

Flint Packer

Great Lakes Clinical Trials - Ravenswood

Recruiting

Chicago, Illinois, United States, 60640

Contacts

773-275-3500 Ext 162

Principal Investigator:

Rupal Trivedi

Iowa Diabetes and Endocrinology Research Center

Recruiting

West Des Moines, Iowa, United States, 50266

Principal Investigator:

Amy Keller

Cotton O'Neil Diabetes & Endocrinology

Recruiting

Topeka, Kansas, United States, 66606

Contacts

785-354-9591

Principal Investigator:

susan brian

AMR Clinical

Recruiting

Lexington, Kentucky, United States, 40509

Contacts

859-264-8999

Principal Investigator:

Mark Adams

IMA Clinical Research Monroe - Armand

Recruiting

Monroe, Louisiana, United States, 71201

Principal Investigator:

Clinton Guillory

Centennial Medical Group

Recruiting

Columbia, Maryland, United States, 21045

Contacts

410-730-3399

Principal Investigator:

Rajiv Dua

Brigham and Women's Hospital Diabetes Program

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

617-732-4245

Principal Investigator:

Vanita Aroda

MedVadis Research Corporation

Recruiting

Waltham, Massachusetts, United States, 02451

Contacts

617-744-1310

Principal Investigator:

David DiBenedetto

Great Lakes Research Institute

Recruiting

Southfield, Michigan, United States, 48075

Contacts

248-864-5242

Principal Investigator:

Derrick Williamson

Revive Research Institute, Inc.

Recruiting

Southfield, Michigan, United States, 48075

Contacts

248-829-3103

Principal Investigator:

Syed Raza

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Recruiting

Troy, Michigan, United States, 48098

Contacts

248-312-0025

Principal Investigator:

Neil Fraser

Clinical Research Professionals

Recruiting

Chesterfield, Missouri, United States, 63005

Contacts

636-220-1200

Principal Investigator:

Timothy Jennings

NYU Langone Health

Recruiting

New York, New York, United States, 10016

Contacts

212-263-3166

Principal Investigator:

Holly Lofton

Weill Cornell Medical College

Recruiting

New York, New York, United States, 10021

Contacts

646-962-2111

Principal Investigator:

Louis Aronne

IMA Clinical Research Manhattan

Recruiting

New York, New York, United States, 10036

Principal Investigator:

Eli Shalenberg

University of North Carolina Medical Center

Recruiting

Chapel Hill, North Carolina, United States, 27514

Contacts

984-974-3004

Principal Investigator:

Klara Klein

Medication Management

Recruiting

Greensboro, North Carolina, United States, 27405

Contacts

336-763-6968

Principal Investigator:

James Franklin

Carteret Medical Group

Recruiting

Morehead City, North Carolina, United States, 28557

Contacts

252-499-8623

Principal Investigator:

Mary Lawrence

Accellacare - Wilmington - 1917 Tradd Court

Recruiting

Wilmington, North Carolina, United States, 28401

Contacts

910-799-5500

Principal Investigator:

John Parker

CTI Clinical Research Center

Recruiting

Cincinnati, Ohio, United States, 45212

Contacts

513-721-3868

Principal Investigator:

Robert Wagner

Care Access - Lima

Recruiting

Lima, Ohio, United States, 45805

Principal Investigator:

Jimmy Alele

Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

Recruiting

Pittsburgh, Pennsylvania, United States, 15236

Contacts

412-650-6155

Principal Investigator:

Bryce Palchick

UT Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75390

Principal Investigator:

Amy Shah

Juno Research

Recruiting

Houston, Texas, United States, 77040

Contacts

713-779-5494

Principal Investigator:

Damaris Vega

Activian Clinical Research

Recruiting

Kingwood, Texas, United States, 77339

Contacts

832-969-3401

Principal Investigator:

Martin Basaldua

Texas Valley Clinical Research (TVCR) - Mission

Recruiting

Mission, Texas, United States, 78572

Principal Investigator:

Alejandro Gonzalez Campos

Synergy Groups Medical LLC - Missouri City

Recruiting

Missouri City, Texas, United States, 77459

Contacts

832-532-4210

Principal Investigator:

Deirdre McMullen

IMA Clinical Research San Antonio

Recruiting

San Antonio, Texas, United States, 78229

Contacts

210-692-7157

Principal Investigator:

Priscilla Thomas

Endeavor Clinical Trials

Recruiting

San Antonio, Texas, United States, 78240

Contacts

518-428-6859

Principal Investigator:

Nitendra Agarwal

Consano Clinical Research, LLC

Recruiting

Shavano Park, Texas, United States, 78231

Contacts

210-545-4900

Principal Investigator:

Michelle Welch

Texas Valley Clinical Research

Recruiting

Weslaco, Texas, United States, 78596

Contacts

956-431-8090

Principal Investigator:

Eduardo Luna

Medrasa Clinical Research

Recruiting

Wylie, Texas, United States, 75098

Contacts

469-449-3645

Principal Investigator:

Tanvir Ahmad

More Information

Sponsor

Eli Lilly and Company

Last update posted

Aug 21, 2026

Last verified

Aug, 2026

Keywords

  • Amylin receptor agonist

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Eli Lilly and Company on 2026-08-21.