Recruiting

Motion Tracking

Sponsor:

University of Maryland, Baltimore

Code:

NCT07398209

Conditions

Lung Cancer (NSCLC)

Radiation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MRI

Study Details

Brief summary:

The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation

Conditions

Lung Cancer (NSCLC)

Radiation

Study ID

NCT07398209

Start date

Apr 14, 2026

Status verified date

Jun, 2026

Completion date

Apr, 2029

Anticipated

Primary completion date

Apr, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC
2. Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy).
3. No restrictions on number radiotherapy fractions, or location/number of lesions
4. ECOG performance status ≤ 3
5. Ability to undergo MRI scans
6. Patient has signed informed consent document and agreed to study procedures

Exclusion Criteria:

1. Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia
2. Women who are pregnant or trying to get pregnant (self-reported)
3. Pain in supine position or inability to raise arm above head in supine position

Study Design

Enrollment

44 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Imaging

At baseline, patients will receive a 4D CT Simulation (standard of care) along with a 4D MRI with surface monitoring (research).

During their radiation treatment, they will receive additional fluoroscopy imaging and surface monitoring.

Interventions

MRI

Baseline 4D CT Simulation and 4S MRI with surface monitoring through EndoScout vest, followed by fluoroscopy and additional surface monitoring while undergoing daily radiation.

Primary outcome measure

  • To investigate if time-resolved, multicycle volumetric motion modeling and monitoring gives improved spatiotemporal localization of the tumor target and OARs compared to current standard-of-care 4DCT-based motion modeling and monitoring [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Amit Sawant, PhD

410-328-6080asawant@som.umaryland.edu

Caitlin Eggleston, MPH

410-369-5351caitlineggleston@umm.edu

Locations

University of Maryland Greenebaum Cancer Center

Recruiting

Baltimore, Maryland, United States, 21201

Contacts

Caitlin Eggleston, MPH

410-369-5351caitlineggleston@umm.edu

More Information

Sponsor

University of Maryland, Baltimore

Last update posted

Jun 26, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Maryland, Baltimore on 2026-06-26.