Recruiting

Menthol E-Cigarettes

Sponsor:

Yale University

Code:

NCT07398976

Conditions

Nicotine Dependence

E-cigarette Use

Eligibility Criteria

Sex: All

Age: 21 - 44

Healthy Volunteers: Accepted

Interventions

Nicotine Level 1 (0mg/ml)

Nicotine Level 2 (36mg/ml)

Nicotine Level 3 (59mg/ml)

Study Details

Brief summary:

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

Conditions

Nicotine Dependence

E-cigarette Use

Study ID

NCT07398976

Start date

Jul 30, 2026

Status verified date

Aug, 2026

Completion date

Apr 1, 2027

Anticipated

Primary completion date

Apr 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 44

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Able to read/write in English
  • Current cigarette smoking
  • Prior e-cigarette exposure
  • Biochemically verified cigarette use
  • Not trying to quit tobacco use

Exclusion Criteria:

  • Significant medical concerns that would increase study risk
  • Use of psychoactive drugs unless prescribed and stable
  • Allergy to menthol or other e-liquid ingredients
  • Dislike of menthol
  • Pregnant, trying to get pregnant, breastfeeding

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Sampling Session - Lab 1

Participants will sample and rate three menthol flavored e-cigarettes with varying levels of nicotine.

experimental: Concurrent Choice Session- Lab 2

Participants will make choices between two menthol e-cigarettes with different levels of nicotine.

Interventions

Nicotine Level 1 (0mg/ml)

Menthol with be paired with 0mg/ml nicotine in an e-cigarette

Nicotine Level 2 (36mg/ml)

Menthol with be paired with 36mg/ml nicotine in an e-cigarette

Nicotine Level 3 (59mg/ml)

Menthol with be paired with 59mg/ml nicotine in an e-cigarette

Primary outcome measure

  • Proportion of Choices [ Time Frame: For the 3 hour period of the Lab 2 preference task ]
  • Breakpoint [ Time Frame: During the 3 hour period of the Lab 2 preference task ]

Central Contacts and Locations

Central contacts

Danielle R Davis, PhD

2039747607danielle.davis@yale.edu

Locations

Yale School of Medicine

Recruiting

New Haven, Connecticut, United States, 06473

Contacts

Danielle R Davis, PhD

203-974-7607danielle.davis@yale.edu

More Information

Sponsor

Yale University

Last update posted

Sep 2, 2026

Last verified

Aug, 2026

Keywords

  • Sex Differences
  • Females
  • E-cigarettes
  • Menthol
  • Nicotine
  • Vaping

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Yale University on 2026-09-02.