Recruiting

Peripheral Venous Pressure vs. No Measurements

Sponsor:

Wake Forest University Health Sciences

Code:

NCT07400042

Conditions

Congestive Heart Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

peripheral venous pressure measurements

standard clinical care

Study Details

Brief summary:

The purpose of the study is to determine if there is a reduction in the length of stay and rates of rehospitalization for patients diagnosed with congestive heart failure when physicians are provided daily measurements of peripheral venous pressure versus no daily measurements of peripheral venous pressure.

Conditions

Congestive Heart Failure

Study ID

NCT07400042

Start date

Jul 27, 2026

Status verified date

Aug, 2026

Completion date

Aug, 2031

Anticipated

Primary completion date

Aug, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with minimum 3-month history of Congestive Heart Failure admitted to Aurora St. Luke's Medical Center with acute decompensation
  • English speaking only

Exclusion Criteria:

  • Patients who do not already have a peripheral IV line inserted
  • Patients whose IV line cannot be transduced
  • Patients with current or past vein thrombosis in the arm used to measure the pressure or with history of recurrent (>1) pulmonary embolism
  • Patients with active thrombophlebitis in the arm
  • Patients who have experienced a major cardiovascular event (myocardial infarction, stroke, etc.) ≤2 months prior to the admission date
  • Patients who have received an implanted cardiac resynchronization device (pacemaker or ICD) ≤3 months prior to admission date
  • Patients enrolled in other cardiovascular research studies.
  • Patients with a clinical condition that the investigator believes may not allow the patient to complete the study, at the discretion of the investigator. Examples of conditions that may apply include severe stenotic valvular disease, isolated right ventricle failure, precapillary pulmonary hypertension, hypertrophic obstructive cardiomyopathy, implanted left ventricular assist device, history of heart transplantation, clinical diagnosis of cardiogenic shock, any left-to-right shunt
  • Patients with congenital heart disease or mechanical right heart valve(s)
  • Planned heart surgery and/or coronary intervention during hospitalization
  • Patients expected to receive heart transplant within 6 months of admission
  • IV cannula smaller than 22G
  • Patients who are pregnant and/or lactating
  • Patients who are unable to provide informed consent
  • Patients who are intubated

Study Design

Enrollment

600 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: peripheral venous pressure measurements

Peripheral venous pressure measures provided to physicians daily up to 8 days

active comparator: standard clinical care

Usual standard clinical care, peripheral venous pressure measures not provided to physician daily

Interventions

peripheral venous pressure measurements

Peripheral venous pressure measures provided to physicians daily up to 8 days, with a research note in the electronic medical record containing standardized recommendations for case also provided daily. Care changes up to clinical provider discretion.

standard clinical care

Usual standard clinical care

Primary outcome measure

  • Length of hospital stay [ Time Frame: up to day 8 ]
  • Number of subjects rehospitalized [ Time Frame: Day 30 post index hospitalization ]
  • Number of subjects rehospitalized [ Time Frame: Month 6 post index hospitalization ]

Central Contacts and Locations

Central contacts

Khawaja Ammar, MD

(414) 649-6181Khawaja.Ammar@aah.org

Locations

Aurora St. Luke's Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Khawaja A Ammar, MD

414-649-6181Khawaja.Ammar@aah.org

More Information

Sponsor

Wake Forest University Health Sciences

Last update posted

Aug 28, 2026

Last verified

Aug, 2026

Keywords

  • peripheral venous pressure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Wake Forest University Health Sciences on 2026-08-28.