Recruiting

TMS

Sponsor:

The University of Texas Health Science Center at San Antonio

Code:

NCT07401225

Conditions

Post Traumatic Stress Disorder (PTSD)

Eligibility Criteria

Sex: All

Age: 12 - 20

Healthy Volunteers: Not accepted

Interventions

MagPro R30 with robotic arm

Study Details

Brief summary:

The purpose of this study is to test whether transcranial magnetic stimulation, or TMS, is an acceptable and helpful treatment for ongoing symptoms of posttraumatic stress syndrome disorder (PTSD) in 12-20 year olds. Ongoing PTSD refers to symptoms that continue after completing trauma-focused psychotherapy. About 1 in 4 patients need additional help to overcome PTSD after completing psychotherapy. Currently, scientists do not know the best way to help adolescents with persistent PTSD, and this study will test TMS as a possible treatment, and hopefully lead to future studies including more people.

Conditions

Post Traumatic Stress Disorder (PTSD)

Study ID

NCT07401225

Start date

May 9, 2026

Status verified date

Jul, 2026

Completion date

Aug 31, 2027

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12 - 20

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Males and females; Age 12-20
2. Have previously completed at least 9 sessions of trauma-focused therapy in our clinical trial or in the community
3. Have current self-reported symptom score of 20 or greater on the UCLA PTSD Reaction index
4. Willing to attend 10 TMS treatment sessions within a 30-day period
5. Fluent in English

Exclusion Criteria:

1. History of seizures
2. History of head injury with loss of consciousness and concussive sequelae
3. Brain abnormality such as tumor or other observable abnormality
4. Currently receiving psychotherapy or TMS treatment
5. Currently pregnant
6. MRI contraindications (metal in body, orthodontic braces)
7. Diagnosis of bipolar 1 or a psychotic disorder

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: TMS treatment group

Each treatment visit will take about 1.5 hours. Participants will receive up to 4 TMS treatment sessions during the visit, with each session lasting about 10-minutes. After the TMS sessions, there will be a brief visit with a psychotherapist.

Interventions

MagPro R30 with robotic arm

TMS will be delivered to the right anterior dorsolateral frontal cortex. The accelerated protocol consists of 1,800 TMS pulses per session, delivered at intensity ranges designed to deliver depth-corrected E-fields of 80-95 volts/meter. The exact intensity will be determined when the participant's treatment plan is developed. Once a patient's TMS treatment plan has been created, it will be used for every treatment session for that participant.

Primary outcome measure

  • Side Effects of TMS treatment [ Time Frame: Day 1 of treatment through Day 30 ]
  • Number of Adverse Events [ Time Frame: Day 1 of treatment through Day 30 ]
  • Completion rate of Treatment [ Time Frame: Day 1 of treatment through Day 30 ]

Central Contacts and Locations

Central contacts

Amy S Garrett, PhD

210-567-8189GarrettAS@uthscsa.edu

Locations

UT Health Department of Psychiatry

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Amy Garrett, PhD

210-567-8189garrettas@uthscsa.edu

More Information

Sponsor

The University of Texas Health Science Center at San Antonio

Last update posted

Jul 13, 2026

Last verified

Jul, 2026

Keywords

  • Transcranial Magnetic Stimulation
  • Transcranial Magnetic Stimulation (TMS)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio on 2026-07-13.