Recruiting

IABC vs. Compliance

Sponsor:

Thomas Jefferson University

Code:

NCT07402018

Conditions

Cardiogenic Shock

IABC Procedure

Intraaortic Balloon Counterpulsation (IABC)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The investigators intend to study how baseline arterial compliance (as defined by stroke volume/pulse pressure) influences the clinical success of intraaortic balloon counterpulsation (IABC) in patients with cardiogenic shock (CS). The investigators aim to compare clinical outcomes in CS patients requiring IABC with normal compliance versus low compliance. The study will enroll patients undergoing IABC that are clinically indicated. Baseline hemodynamic measurements will be obtained and then patients would be stratified based on their compliance. Post IABC, serial hemodynamic measurements will be obtained and compared between groups. Patients will continue to be followed longitudinally until the IABC has been discontinued for any reason. The proposed study will yield results that will aid in developing a larger clinical trial and ultimately assist clinicians in determining if IABC is appropriate therapy for patients in cardiogenic shock.

Conditions

Cardiogenic Shock

IABC Procedure

Intraaortic Balloon Counterpulsation (IABC)

Study ID

NCT07402018

Start date

Jan 27, 2026

Status verified date

Nov, 2025

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥18 years old
  • Cardiogenic shock
  • Undergoing Intra-aortic Balloon Counterpulsation (IABC) as part of clinical care
  • Able to provide consent or have power of attorney or next of kin provide consent

Exclusion Criteria:

  • Age <18 years old
  • Unable to consent or does not have power of attorney or next of kin to consent

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Cardiac Output (L/min) [ Time Frame: 24 hours ]

Central Contacts and Locations

Central contacts

Matthew S Delfiner, DO, MS

215-955-2050

Locations

Thomas Jefferson University Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Principal Investigator:

Matthew S Delfiner, DO, MS

More Information

Sponsor

Thomas Jefferson University

Last update posted

Feb 11, 2026

Last verified

Nov, 2025

Keywords

  • Cardiogenic shock

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Thomas Jefferson University on 2026-02-11.