Recruiting

Observational Study

Sponsor:

State University of New York at Buffalo

Code:

NCT07403539

Conditions

Parkinson's Disease

Eligibility Criteria

Sex: All

Age: 45+

Healthy Volunteers: Not accepted

Interventions

Intensity learning

Intensity discrimination

Rate learning

Rate discrimination

Study Details

Brief summary:

Parkinson's disease, a common movement disorder that results from a breakdown in the brain, often leads to challenges with talking, but less is known about the relationship between difficulties with talking and difficulties with learning to understand speech. By linking these two abilities in individuals with Parkinson's disease using a precision medicine approach, this project seeks to build a basis for new therapies that help people with Parkinson's disease both understand better and speak more clearly.

Conditions

Parkinson's Disease

Study ID

NCT07403539

Start date

Jan 27, 2026

Status verified date

Feb, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 45+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of Parkinson's disease
  • Native speaker of North American English
  • Use a drug that includes levodopa
  • Resident of the United States

Exclusion Criteria:

  • Any history of language, hearing or speech disorder outside of Parkinson's disease
  • Other gross neurological impairment such as Alzheimer's disease or stroke
  • Significant hearing loss and/or use of a hearing aid or cochlear implant

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Learning and Discrimination

Behavioral interventions will be administered, including speech intensity learning, speech intensity discrimination, speech rate learning, and speech rate discrimination

Interventions

Intensity learning

Participants will be asked to pair sentences that vary in their sound intensity to one of three colored squares (red, yellow, or blue)

Intensity discrimination

Participants will hear two sentences that are either the same or different in their sound intensity and will be asked to indicate whether the sentences were of the same or different intensities

Rate learning

Participants will be asked to pair sentences that vary in their spoken rate to one of three colored squares (red, yellow, or blue)

Rate discrimination

Participants will hear two sentences that are either the same or different in their spoken rate and will be asked to indicate whether the sentences were of the same or different rates

Primary outcome measure

  • Mean dB SPL [ Time Frame: Day 1 ]
  • Standard deviation dB SPL [ Time Frame: Day 1 ]
  • Speaking rate [ Time Frame: Day 1 ]
  • Articulation rate [ Time Frame: Day 1 ]
  • Unfilled pause time [ Time Frame: Day 1 ]

Central Contacts and Locations

Locations

State University of New York at Buffalo

Recruiting

Buffalo, New York, United States, 14214

Contacts

Jordana Maisel

1 (716) 829-5902jlmaisel@buffalo.edu

More Information

Sponsor

State University of New York at Buffalo

Last update posted

Feb 11, 2026

Last verified

Feb, 2026

Keywords

  • speech perception
  • communication
  • learning

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by State University of New York at Buffalo on 2026-02-11.