Recruiting

DSLT vs. SLT

Sponsor:

Medical University of South Carolina

Code:

NCT07408154

Conditions

Open-angle Glaucoma (OAG)

Ocular Hypertension (OHT)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Direct Selective laser Trabeculoplasty

Study Details

Brief summary:

This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.

Conditions

Open-angle Glaucoma (OAG)

Ocular Hypertension (OHT)

Study ID

NCT07408154

Start date

Apr 27, 2026

Status verified date

May, 2026

Completion date

Oct, 2027

Anticipated

Primary completion date

Oct, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥18 years
  • Diagnosis of OAG (including exfoliative or pigmentary) or OHT
  • Gonioscopically open angle (visible scleral spur 360°)
  • Ability to consent and comply with follow-up

Exclusion Criteria:

  • Angle-closure or secondary glaucomas
  • IOP >35 mmHg despite therapy
  • Corneal pathology interfering with laser or IOP measurement
  • Recent ocular surgery (<6 months)
  • Contraindications to study medications or procedures
  • Cognitive impairment preventing consent

Study Design

Enrollment

172 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Direct Selective Laser Trabeculoplasty

This arm is going to receive the Direct SLT treatment

active comparator: Traditional Selective Laser Trabeculoplasty

This arm is going to receive the Traditional SLT treatment which will act as a control for the experimental arm. Note that both lasers are Standard of Care (SOC) and FDA approved

Interventions

Direct Selective laser Trabeculoplasty

The Direct Selective Laser Trabeculoplasty is a non-contact laser designed to manage IOP in patients with glaucoma. The traditional SLT required a gonioscopy lens to be placed over the patient's eyes to direct the laser towards the trabecular meshwork.

Primary outcome measure

  • Change in Intraocular Pressure at 12 months from baseline [ Time Frame: 12 months ]

Central Contacts and Locations

Locations

MUSC

Recruiting

Charleston, South Carolina, United States, 29407

Contacts

Jella An, MD, MBA

843-792-1443anjel@musc.edu

Principal Investigator:

Jella An, MD, MBA

More Information

Sponsor

Medical University of South Carolina

Last update posted

May 6, 2026

Last verified

May, 2026

Keywords

  • Glaucoma
  • Open-Angle Glaucoma
  • Ocular Hypertension
  • Laser Trabeculoplasty
  • Intraocular Pressure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-05-06.