Recruiting

Biofeedback Training

Sponsor:

University Health Network, Toronto

Code:

NCT07409077

Conditions

Glaucoma

Biofeedback Training

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Biofeedback Training

Study Details

Brief summary:

This randomized controlled clinical trial evaluates the efficacy of visual biofeedback training on visual function and quality of life in individuals with glaucoma. Glaucoma is a progressive optic neuropathy that can lead to irreversible vision loss, including impaired fixation stability, reduced retinal sensitivity, and decreased functional vision. Biofeedback training is a visual rehabilitation technique designed to help patients improve fixation stability and optimize use of remaining visual function by training eye movements toward retinal areas with better sensitivity.

Seventy participants with glaucoma will be randomized to either a biofeedback training intervention group or a control group. Visual function outcomes, including fixation stability, retinal sensitivity, visual acuity, reading speed, contrast sensitivity, and quality of life, will be assessed at baseline and follow-up visits. This study aims to determine whether biofeedback training can improve visual function and quality of life in patients with glaucoma.

Conditions

Glaucoma

Biofeedback Training

Study ID

NCT07409077

Start date

Feb 10, 2026

Status verified date

Feb, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Jan 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18-95 years old.
  • Glaucoma cases with adequate intraocular pressure control.
  • Presence of paracentral scotomata within two degrees of fixation.
  • Ability to follow instructions for biofeedback training.

Exclusion Criteria:

  • Prior or current low vision rehabilitation treatment.
  • Ocular diseases or severe clinical conditions unrelated to glaucoma
  • Media opacities that prevent reliable microperimetry testing in both eyes.
  • Inability to perform study assessments or follow instructions for biofeedback training.

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Biofeedback Training (BT)

Participants randomized to this arm will receive visual biofeedback training in addition to standard clinical care. The intervention consists of five weekly in-office training sessions, each lasting approximately 20 minutes. During training, participants are guided using visual and auditory feedback to direct eye movements toward a preferred retinal locus with better retinal sensitivity and fixation stability. Visual function and quality of life assessments will be conducted at baseline and at scheduled follow-up visits.

active comparator: Control (Delayed Biofeedback Training)

Participants randomized to this arm will undergo standard clinical assessments without biofeedback training during the initial study period. Visual function and quality of life assessments will be conducted at baseline and at the 9-week follow-up visit. After completion of the control period, participants will be offered biofeedback training as part of standard clinical care.

Interventions

Biofeedback Training

Visual Biofeedback Training

Primary outcome measure

  • Quality of Life Questionnaire [ Time Frame: Baseline, 9 weeks, 6 months, 1 year and 2 years. ]
  • Visual acuity [ Time Frame: Baseline and follow-up visits at 9 weeks, 6 months, 1 year, and 2 years post-intervention ]
  • Fixation Stability [ Time Frame: Baseline, 9 weeks, 6 months, 1 year and 2 years. ]

Central Contacts and Locations

Locations

University Health Network/ Toronto Western Hospital

Recruiting

Toronto, Ontario, Canada, M5T 2S8

Contacts

Monica Daibert-Nido, MD

416-603-5470monica.nido@uhn.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Feb 13, 2026

Last verified

Feb, 2026

Keywords

  • glaucoma
  • biofeedback training

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-02-13.