Recruiting

MiraBurst

Sponsor:

Case Comprehensive Cancer Center

Code:

NCT07419581

Conditions

Dysgeusia

Solid Tumor

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MiraBurst

Study Details

Brief summary:

This study is for people with a diagnosis of solid tumor cancer who are experiencing changes in taste perception due to cancer treatment. Changes in taste perception, also known as dysgeusia, is a frequent side effect of cancer treatment and can significantly impacts quality of life. These alterations may be temporary or, in some cases, permanent.

The purpose of this study is determine whether freeze dried miracle fruit, marketed as MiraBurst can improve taste perception in this group of people. Participants involved in this study will be asked to take one MiraBurst mini-square upto four times a day, prior to eating, for 90 days.

Conditions

Dysgeusia

Solid Tumor

Study ID

NCT07419581

Start date

Sep, 2026

Status verified date

Oct, 2026

Completion date

Mar, 2028

Anticipated

Primary completion date

Mar, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years and above
  • Solid tumor cancer diagnosis
  • Participants on active cancer treatment
  • Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
  • Grade 2 dysgeusia related to cancer treatment per Common Terminology Criteria for Adverse Events (CTCAE) version 6.0

Exclusion Criteria:

  • Grade 2 dysgeusia prior to starting cancer treatment
  • Participants with severe dementia, severe neurological illness who are unable to understand the study or provide informed consent
  • Participants on enteral and parenteral nutrition
  • Participants with eating disorders
  • Pregnancy
  • Participants with uncontrolled acute medical issues (e.g., acute angina, acute stroke, uncontrolled diabetes mellitus, uncontrolled hypertension etc.) that, per investigator's assessment, would contraindicate the study treatment

Study Design

Enrollment

45 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: MiraBurst

Participants will consume one MiraBurst mini-square prior to each meal (up to four times per day) for a 90 day period.

Interventions

MiraBurst

Participants will consume one 300 milligram (mg) MiraBurst mini-square prior to each meal (up to four times per day) for a 90 day period.

Primary outcome measure

  • Evaluate effect on taste perception [ Time Frame: Baseline (Day 1), Day 7 ]
  • Evaluate effect on taste perception [ Time Frame: Baseline (Day 1), Day 28 ]
  • Evaluate effect on taste perception [ Time Frame: Baseline (Day 1), Day 90 ]
  • Evaluate effect on taste perception [ Time Frame: Baseline (Day 1), Day 120 ]

Central Contacts and Locations

Central contacts

Shirley Thomas, MD, MRCP (UK), MRCP (UK) Pall Med, PGDip Pall Med

216-445-0132thomass75@ccf.org

Locations

Cleveland Clinic Foundation

Recruiting

Cleveland, Ohio, United States, 44195

Contacts

Shirley Thomas, MD MRCP (UK), MRCP (UK) Pall Med, PGDip Pall Med

216-445-0132thomass75@ccf.org

Principal Investigator:

Shirley Thomas, MD MRCP (UK), MRCP (UK) Pall Med, PGDip Pall Med

More Information

Sponsor

Case Comprehensive Cancer Center

Last update posted

Oct 28, 2026

Last verified

Oct, 2026

Keywords

  • Freeze-Dried Miracle Fruit
  • MiraBurst

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-29. This information was provided to ClinicalTrials.gov by Case Comprehensive Cancer Center on 2026-10-28. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.