Recruiting

Heat & Moisture Exchanger

Sponsor:

Laval University

Code:

NCT07420673

Conditions

Mechanical Ventilator Care

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Expiratory gases temperature

Study Details

Brief summary:

Adequate humidification is essential for intubated patients because dry medical gases can cause thick secretions and dangerous endotracheal tube blockages. A clear correlation exists between exhaled and inhaled humidity delivered by heat and moisture exchanger. The objective of this study is to measure the temperature of exhaled gases in intubated patients in order to accurately calculate the absolute humidity during the expiratory phase. These data will allow for a more accurate reproduction of real clinical conditions during bench testing and will improve the assessment of heat and moisture exchanger performance device evaluation.

Conditions

Mechanical Ventilator Care

Study ID

NCT07420673

Start date

May 25, 2026

Status verified date

Nov, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults (≥18 years)
  • Intubated and mechanically ventilated in the intensive care unite
  • Using passive humidification (Heat and Moisture exchanger)

Exclusion Criteria:

  • PEEP set < 12 cmH₂O
  • Inhaled nitric oxide therapy
  • Tracheostomy

Study Design

Enrollment

70 participants

Anticipated

Interventions and Outcome Measures

Arms

Normothermic patient

Normothermic patient under mechanical ventilation with passive humification (heat and moisture exchanger) with body temperature between 36.0 and 38.0 Celsius degrees

Hypothermic patient

Hypothermic patient under mechanical ventilation with passive humification (heat and moisture exchanger) with body temperature < 36.0 Celsius degrees

Hyperthermic patient

Hyperthermic patient under mechanical ventilation with passive humification (heat and moisture exchanger) with body temperature > 38.0 Celsius degrees

Interventions

Expiratory gases temperature

Measure expiratory gas temperature immediately before the passive humidifier in intubated ICU patients and evaluate the relationship between body temperature and expiratory temperature.

Primary outcome measure

  • Expiratory gas temperature [ Time Frame: H0, up to 60 minutes after inclusion ]
  • Relationship between body temperature and expiratory temperature. [ Time Frame: H0, up to 60 minutes after inclusion ]

Central Contacts and Locations

Central contacts

Francois Lellouche, MD, PhD

1 418-656-8711francois.lellouche@criucpq.ulaval.ca

Locations

Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

Francois Lellouche Principal Investigator

418-656-8711francois.lellouche@criucpq.ulaval.ca

More Information

Sponsor

Laval University

Last update posted

Nov 5, 2026

Last verified

Nov, 2026

Keywords

  • humidification
  • Passive humidification

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-06. This information was provided to ClinicalTrials.gov by Laval University on 2026-11-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.