Recruiting

Marijuana & Anesthesia

Sponsor:

University of Michigan

Code:

NCT07423195

Conditions

Cannabis Use

Marijuana Usage

Sedation and Analgesia

Wisdom Tooth

Eligibility Criteria

Sex: All

Age: 16 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study is for people scheduled to have their wisdom teeth (third molars) removed and are going to receive drug through an IV to put them to sleep.

The researchers are studying two groups: one group of people who report using recreational marijuana/THC/cannabis and another group who report not using it. They want to look at how both users and non-users do during the tooth removal.

Conditions

Cannabis Use

Marijuana Usage

Sedation and Analgesia

Wisdom Tooth

Study ID

NCT07423195

Start date

Jan 14, 2026

Status verified date

Feb, 2026

Completion date

Jan, 2030

Anticipated

Primary completion date

Jan, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 16 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Provide a signed and dated informed consent form.
  • Willing to comply with all study procedures and be available for the duration of the study.
  • Aged ≥ 16 years old.
  • Presence at least one mandibular 3rd molar
  • American Society of Anesthesiologists (ASA) physical status class I or II

Exclusion Criteria:

  • Pathology (cyst or tumor) associated with the third molar tooth;
  • Health comorbidities (BMI 40 and above, and severe cardiovascular disease);
  • Pregnancy or lactation
  • Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Study Design

Enrollment

242 participants

Anticipated

Interventions and Outcome Measures

Arms

marijuana/THC/cannabis users

marijuana/THC/cannabis users

Non marijuana/THC/cannabis users

Non marijuana/THC/cannabis users

Primary outcome measure

  • Midazolam administered [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration ]
  • Mean arterial pressure [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration. ]
  • Heart rate [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration. ]
  • Carbon dioxide level [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration. ]
  • Ketamine administered [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration ]
  • Fentanyl administered [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration ]
  • Propofol administered [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration ]
  • Respiratory rate [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration. ]
  • Oxygen saturation [ Time Frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration. ]

Central Contacts and Locations

Central contacts

Jennifer A Lay-Luskin, MPhil, CCRC

Oral and Maxillofacial Surgeryjalay@umich.edu

Bradley Blitstein, DDS

734-936-0864bjblitst@umich.edu

Locations

University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Jennifer Lay-Luskin, MPhil, CCRC

734-763-5963jalay@umich.edu

More Information

Sponsor

University of Michigan

Last update posted

Feb 20, 2026

Last verified

Feb, 2026

Keywords

  • Wisdom tooth
  • Cannabis use
  • Sedation and analgesia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Michigan on 2026-02-20.