Recruiting

Photobiomodulation

Sponsor:

Columbia University

Code:

NCT07425080

Conditions

IVF Outcomes

Eligibility Criteria

Sex: Female

Age: 18 - 48

Healthy Volunteers: Accepted

Interventions

Photobiomodulation

Study Details

Brief summary:

Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.

Conditions

IVF Outcomes

Study ID

NCT07425080

Start date

Mar 24, 2026

Status verified date

Mar, 2026

Completion date

Jun 1, 2028

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 48

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Female age between 18-48 years at the time of the IVF/ICSI cycle
  • Undergoing blastocyst culture
  • Using own oocytes
  • Has at least two oocytes available for randomization
  • Consenting to oocyte level randomization
  • Plan to transfer euploid embryo within 6 months

Exclusion Criteria:

  • Use of donor oocytes or gestational carrier
  • Concurrent experimental laboratory inventions outside of protocol
  • Refusal of randomization or request for non-standard handling

Study Design

Enrollment

270 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: No photobiomodulation

Participants will receive the same treatment (IVF/ICSI cycles with PGT-A). Participant's resultant oocytes will be randomized to not receive PBM.

experimental: Photobiomodulation

Participants will receive the same treatment (IVF/ICSI cycles with PGT-A). Participant's resultant oocytes will be randomized to receive PBM.

Interventions

Photobiomodulation

Photobiomodulation (PBM): also known as low-level light therapy (LLLT), involves the application of low-intensity red or near-infrared (NIR) light to modulate mitochondrial activity.

Primary outcome measure

  • Number of usable blastocysts [ Time Frame: Seven days post egg retrieval ]

Central Contacts and Locations

Central contacts

Samuel Zev Williams, MD, PhD

646-756-8282zw2421@cumc.columbia.edu

Laura C Gemmell, MD, MSc

646-756-8282lg3094@cumc.columbia.edu

Locations

Columbia University Fertility Center

Recruiting

New York, New York, United States, 10019

Contacts

Laura C Gemmell, MD, MSc

646-756-8282lg3094@cumc.columbia.edu

Stephanie Morgan, MS

646-756-8282sm3415@cumc.columbia.edu

Principal Investigator:

Samuel Z Gemmell, MD, PhD

More Information

Sponsor

Columbia University

Last update posted

Mar 25, 2026

Last verified

Mar, 2026

Keywords

  • Infertility
  • Embryo arrest
  • Fertility

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-03. This information was provided to ClinicalTrials.gov by Columbia University on 2026-03-25.