Recruiting

WeCan-Rural

Sponsor:

Duke University

Code:

NCT07426952

Conditions

Breast Cancer Survivorship

Weight Management

Cardiovascular (CV) Risk

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

WeCan-Rural Program

Study Details

Brief summary:

This study is testing a new program called WeCan-Rural, designed to help breast cancer survivors manage symptoms and build healthy habits like eating well, staying active, and managing their weight. These changes may help lower the risk of heart disease after cancer treatment.

The study will answer two main questions:

  • Can study team successfully recruit and keep participants in the study, and will the participants find the program helpful and easy to follow?
  • Will participants who join the program see better results in areas like weight, symptoms, diet, physical activity, and confidence in managing the participant's health compared to those who receive standard care?

Here's what participants will do:

  • Visit the participant's clinic twice (about 12 weeks apart) to be weighed, have the blood pressure checked, give a blood sample, and complete a short walking test
  • Fill out online surveys about the participant's health, diet, physical activity, symptoms, and confidence in managing the participant's health
  • Be randomly assigned (like flipping a coin) to either receive the WeCan-Rural program or standard health information
  • If assigned to the program, attend 12 weekly one-hour video sessions on Zoom with a trained therapist

Conditions

Breast Cancer Survivorship

Weight Management

Cardiovascular (CV) Risk

Breast Cancer

Study ID

NCT07426952

Start date

Aug, 2026

Status verified date

Aug, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • aged 18 years or older
  • female (biological sex)
  • diagnosis of stage I-III breast cancer
  • completed treatments with curative intent (with the exception of hormonal treatments) in the last 5 years
  • body mass index >30
  • healthy enough to participate in home-based physical activity
  • able to speak/read English
  • reports rating of ≥4 (i.e., moderate or more severe) out of 10 for one or more of the following symptoms at its worst in the last month (per the MD Anderson Symptom Inventory): pain, fatigue, sadness, and/or distress

Exclusion Criteria:

  • visual, hearing or cognitive impairment or severe mental illness interfering with participation

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: WeCan-Rural

Participants will receive the WeCan-Rural intervention, which includes twelve sessions delivered remotely (i.e., videoconferencing) by a trained therapist.

no intervention: Control

Participants will receive the National Cancer Institute-developed booklet "Facing Forward: Life After Cancer Treatment," which presents information about cancer survivorship topics.

Interventions

WeCan-Rural Program

The WeCan-Rural program includes 12, one-hour weekly sessions via Zoom that help breast cancer survivors manage symptoms like pain, fatigue, and emotional distress, while also building healthy habits around eating, exercise, and weight management.

Primary outcome measure

  • Satisfaction with Treatment and Interventionist as measured by the Satisfaction with Therapy and Therapist Scale-Revised (STTS-R) [ Time Frame: Post-treatment (about 12-14 weeks after baseline) ]
  • Acceptability as measured by the Treatment Acceptability Questionnaire [ Time Frame: Post-treatment (about 12-14 weeks after baseline) ]

Central Contacts and Locations

Central contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Michael W Willis

919-681-8437michael.w.willis@duke.edu

Locations

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27705

Contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Caroline Dorfman, PhD

919-416-3473caroline.dorfman@duke.edu

Maria Parham Cancer Center

Recruiting

Henderson, North Carolina, United States, 27536

Contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Caroline Dorfman, PhD

919-416-3473caroline.dorfman@duke.edu

Scotland Health

Recruiting

Laurinburg, North Carolina, United States, 28352

Contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Caroline Dorfman, PhD

919-416-3473caroline.dorfman@duke.edu

UNC Health Southeastern

Recruiting

Lumberton, North Carolina, United States, 28358

Contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Caroline Dorfman, PhD

919-416-3473caroline.dorfman@duke.edu

UNC Health Johnston

Recruiting

Smithfield, North Carolina, United States, 27577

Contacts

Smrithi Divakaran, MPH

919-681-7695smrithi.divakaran@duke.edu

Caroline Dorfman, PhD

919-416-3473caroline.dorfman@duke.edu

More Information

Sponsor

Duke University

Last update posted

Aug 13, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Duke University on 2026-08-13.