Recruiting

AtropineAPPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes

Sponsor:

UCLA

Code:

NCT07434635

Conditions

Eye Disorders

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Atropine 1%

Study Details

Brief summary:

The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.

Conditions

Eye Disorders

Study ID

NCT07434635

Start date

Mar 10, 2026

Status verified date

Jul, 2026

Completion date

Feb, 2029

Anticipated

Primary completion date

Feb, 2028

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

patient undergoing vitrectomy surgery
able to give informed consent

Exclusion Criteria:

post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications
subjects with altered post-operative eyedrop schedule for enhanced inflammation control
documented allergy to atropine

Study Design

Enrollment

62 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: Control

No atropine

experimental: Experimental

Participant uses atropine eyedrops

Interventions

Atropine 1%

Subtraction of atropine eyedrops from post-operative treatment regimen

Primary outcome measure

Pain score on the Visual Analog Scale (VAS) [ Time Frame: 1 month ]

Central Contacts and Locations

Central contacts

Jay Stewart, MD

415-353-9635 eyestudy@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Jay Stewart

415-353-9635 eyestudy@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Jul 31, 2026

Last verified

Jul, 2026

Keywords

atropine
eye surgery

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-07-31.