Recruiting

Genetic Counseling

Sponsor:

Barbara Ann Karmanos Cancer Institute

Code:

NCT07436078

Conditions

Female Breast Cancer

Prostate Cancer

Colorectal Carcinoma

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

Culturally adapted Online Genetic Counseling and Testing Information

Study Details

Brief summary:

The goal of this clinical trial is to culturally adapt an educational genetic counseling intervention to increase the uptake in genetic counseling and testing among African Americans at risk for heredity cancers. With the help of community stakeholders and clinical genetic professionals the investigators will:

  • adapt and refine a culturally relevant online educational genetic counseling program for at-risk African Americans
  • Test the effects of the educational program
  • collaborate with community leaders and clinical genetic professionals to translate study findings, develop a road map for dissemination to the community, and identify barriers to prepare for future trials.

Participants from Detroit Research on Cancer Survivor group will be offered enrollment. Once consent is obtained, questionnaires will be completed before an online genetic counselling intervention immediately after, and at 3 months

Conditions

Female Breast Cancer

Prostate Cancer

Colorectal Carcinoma

Study ID

NCT07436078

Start date

Apr 18, 2026

Status verified date

Jun, 2026

Completion date

Jul, 2029

Anticipated

Primary completion date

Jul, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS)
  • Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013
  • have received or currently receiving care at Karmanos Cancer Institute
  • meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below

Female breast

1. personal diagnosis at age ≤50
2. personal history of the triple-negative subtype
3. at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age <50
4. at least 1 close relative diagnosed with ovarian cancer
5. 2+ close relatives diagnosed with breast or prostate cancer
6. age <50 AND another primary breast cancer at any age
7. 2+ primary breast cancers at any age

OR Prostate

1. personal history of high-risk or very high-risk prostate cancer
2. personal history of regional or metastatic prostate cancer
3. personal history of less than high-risk prostate cancer with a suggestive family history (i.e., father or brother or multiple relatives with prostate cancer diagnosed at age <60; at least 1 relative with breast, ovarian, or pancreatic cancer; or at least 1 relative with colorectal, ovarian, pancreatic, or kidney cancer)

OR Colorectal

1. personal diagnosis at age ≤50
2. at least 1 close relative diagnosed with HNPCC at age <50
3. at least 2 close relatives diagnosed with an HNPCC cancer at any age
4. colorectal and >=1 primary endometrial, ovarian, gastric, pancreatic, or prostate

Exclusion Criteria:

  • Previous genetic counseling and/or testing

Study Design

Enrollment

85 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Online Culturally adapted Genetic Counseling Information

Culturally developed online Genetic counseling information will be provided. Questionnaires will be administered pre and post genetic counseling intervention as well as 3 months post intervention

Interventions

Culturally adapted Online Genetic Counseling and Testing Information

Testing the effects of the educational intervention designed to increase the uptake of genetic counseling testing among at-risk African American survivors

Primary outcome measure

  • Uptake of genetic counseling and genetic testing [ Time Frame: 3 month follow Up ]

Central Contacts and Locations

Central contacts

Locations

Karmanos Cancer Institute

Recruiting

Detroit, Michigan, United States, 48201

Contacts

Principal Investigator:

Felicity WK Harper, Ph.D

More Information

Sponsor

Barbara Ann Karmanos Cancer Institute

Last update posted

Jun 23, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Barbara Ann Karmanos Cancer Institute on 2026-06-23.