Recruiting

Virtual Reality Therapy

Sponsor:

Palo Alto University

Code:

NCT07437872

Conditions

no Interaction VRET

Scripted Interactions VRET

Fully Customized Interactions VRET

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

ExpandXR

Study Details

Brief summary:

The purpose of this study is to test mechanisms and processes of virtual reality and augmented reality exposure therapy for social anxiety. There is substantial evidence that virtual reality exposure therapy is an effective treatment for social anxiety. However, it can be difficult to access treatment that needs to be conducted in person. Tests of self-guided (without therapist assistance) virtual reality exposure therapy have had mixed efficacy and tests of augmentation offer an important method to optimize brief interventions. The study objectives are to test a wide range of possible mechanisms and approaches (ranging from single sessions in person to remotely conducted virtual reality exposure therapy) in order to advance the field. The broadness of the proposed research is to provide multiple avenues for inquiry per discussion with IRB chair Dr. Kuo. Depending on the specific line of inquiry some variations will be documented (e.g., multiple consent forms for answering different sub questions of the primary questions listed below).

Conditions

no Interaction VRET

Scripted Interactions VRET

Fully Customized Interactions VRET

Study ID

NCT07437872

Start date

Feb 24, 2026

Status verified date

Mar, 2026

Completion date

Mar 1, 2028

Anticipated

Primary completion date

Feb 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Individuals at least 18 years of age
  • Located in the U.S. with sufficient proximity to Mountain View Campus to attend in person visit(s).
  • Able to give consent
  • Social Anxiety Disorder based on Structured Clinical Interview AND/OR self-report score cutoff (LSAS > 47).

Exclusion Criteria:

  • Current Alcohol or Substance Use Disorder (based on self-report)
  • Current or prior psychotic related or bipolar disorder (based on self-report)
  • Unstable psychotropic medication (starting/stopping medication in past 6 weeks based on selfreport)
  • Current cognitive behavioral therapy for social anxiety
  • Impaired vision such that cannot see in VR headset without glasses (contacts okay)

Study Design

Enrollment

45 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: no interaction Virtual Reality Exposure Therapy

experimental: structured interaction Virtual Reality Exposure Therapy

experimental: personalized interaction Virtual Reality Exposure Therapy

Interventions

ExpandXR

An Mixed Reality Exposure Therapy platform for the Apple Vision Pro

Primary outcome measure

  • Liebowitz Social Anxiety Scale Self Report Version [ Time Frame: Baseline ]
  • Liebowitz Social Anxiety Scale Self Report Version [ Time Frame: 21 days ]
  • Liebowitz Social Anxiety Scale Self Report Version [ Time Frame: 51 days ]
  • Liebowitz Social Anxiety Scale Self Report Version [ Time Frame: 111 days ]
  • Personal Report of Communication Apprehension (PRCA) [ Time Frame: Baseline ]
  • Personal Report of Communication Apprehension (PRCA) [ Time Frame: 21 days ]
  • Personal Report of Communication Apprehension (PRCA) [ Time Frame: 51 days ]
  • Personal Report of Communication Apprehension (PRCA) [ Time Frame: 111 days ]

Central Contacts and Locations

Locations

Palo Alto University Mountain View Campus

Recruiting

Palo Alto, California, United States, 94304

Contacts

Principal Investigator:

Mikael Rubin, PhD

More Information

Sponsor

Palo Alto University

Last update posted

Mar 4, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Palo Alto University on 2026-03-04.