Recruiting

Nutritional Supplement

Sponsor:

Athletic Greens International

Code:

NCT07437911

Conditions

Nutrition Intake

Nutrition Status

Gastrointestinal Microbiome

GLP-1

Eligibility Criteria

Sex: All

Age: 18 - 59

Healthy Volunteers: Not accepted

Interventions

AG1 - Nutritional Supplement

Placebo

Study Details

Brief summary:

This study is a triple-blind, placebo-controlled, randomized controlled trial of 120 adults that will evaluate the impact of a novel nutritional supplement on improving nutrient gaps and changing nutrient status and the gut microbiome among glucagon-like peptide-1 receptor agonist (GLP-1 RA) users.

Conditions

Nutrition Intake

Nutrition Status

Gastrointestinal Microbiome

GLP-1

Study ID

NCT07437911

Start date

Feb, 2026

Status verified date

Feb, 2026

Completion date

Aug, 2026

Anticipated

Primary completion date

Aug, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 59

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Be male or female
  • Be aged 18-59.
  • Has a BMI between 20-31.9.
  • Anyone currently taking GLP-1 medication at their maintenance dose (week 8+), and without any plans to alter their dosage. This includes: Semaglutide (Ozempic®, Wegovy®, Rybelsus®), Liraglutide (Saxenda®, Victoza®), Dulaglutide (Trulicity®), Exenatide (Byetta®, Bydureon®), Lixisenatide (Adlyxin®)
  • Anyone willing to follow the study protocol, including immediately prior to the all blood tests, duplicating their diet for 72 hours (3 days), refraining from caffeine and exercise for 24 hours, and fasting for 10 hours.
  • Anyone willing to maintain their current diet, sleep pattern, and activity levels for the duration of the trial.
  • Anyone willing to avoid introducing any other supplements, medications, or herbal remedies for the duration of this trial.
  • Anyone who is generally healthy - does not live with any diagnosed uncontrolled chronic disease.
  • Has access to a consistent weighing scale for the duration of the study.
  • Resides in the United States.

Exclusion Criteria:

  • Anyone with a diagnosis of Type I or Type II diabetes.
  • Anyone with a diagnosis of any metabolic health condition, such as hypertension and dyslipidemia.
  • Anyone who has taken any multivitamin/multimineral supplements within the past 3 months.
  • Anyone who has taken a probiotic supplement within the past month.
  • Anyone who has regularly consumed (5 days/week or more) products that target healthy aging, anti-aging, longevity, gut health, energy, or ingestive behaviour (such as cravings), including resveratrol, quercetin, pterostilbene, coQ10, grapefruit, nicotinamide riboside, prebiotic fiber, green tea, niacin (vitamin B3) within the past 2 months.
  • Anyone who has received an antibiotic, antifungal, antiparasitic, or antiviral treatment within the past 90 days.
  • Anyone who has a known history of severe digestive disorders or metabolic conditions that impact nutrient absorption or metabolism, including acid reflux, Irritable Bowel Syndrome (IBS), Irritable Bowel Disease (IBD), Crohn's disease, a history of colon resection, gastroparesis, Inborn errors of metabolism (such as PKU), or gastrointestinal tract surgeries.
  • Anyone with any known allergies or hypersensitivities to any supplement product ingredients.
  • Anyone with any chronic health conditions that could impact participation in this study, such as asthma, gout, fibromyalgia, chronic inflammatory conditions (such as Crohn's, Lupus, HIV/AIDS), thyroid conditions, cancer (within the past 5 years), mental health disorders, history of serious illness in the last three months, history of substance abuse, or planned surgery during the study period.
  • Anyone currently pregnant, trying to conceive, or breastfeeding.
  • Anyone who has undergone a change in hormone therapy (including oral contraceptives) within the past 4 weeks, or is unwilling to maintain their current hormone therapy/oral contraceptive use throughout the course of the study.
  • Anyone who consumes more than 2 standard alcoholic drinks per day or more than 10 drinks per week, or has within the past 6 months.
  • Anyone who is currently a smoker or has been a smoker within the past month.
  • Anyone who follows a specific exclusion diet, including vegan, vegetarian, carnivore, paleo, atkins, or ketogenic.

Study Design

Enrollment

120 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Dietary Supplement: AG1 - Nutritional Supplement

AG1 - Nutritional Supplement

placebo comparator: Dietary Supplement: Placebo

Interventions

AG1 - Nutritional Supplement

AG1 - Nutritional Supplement

Placebo

Maltodextrin Placebo

Primary outcome measure

  • Nutrient Gaps [ Time Frame: 90 days ]

Central Contacts and Locations

Central contacts

Ellen O'Gorman

(805) 292-0714ellen@citruslabs.com

Jodi Nicolli

jodi@citruslabs.com

Locations

Citruslabs

Recruiting

Santa Monica, California, United States, 90404-3727

Contacts

Principal Investigator

(805) 292-0714ellen@citruslabs.com

Director of Customer Success

jodi@citruslabs.com

More Information

Sponsor

Athletic Greens International

Last update posted

Feb 27, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Athletic Greens International on 2026-02-27.