Recruiting

Remote Exercise Intervention

Sponsor:

Jonsson Comprehensive Cancer Center

Code:

NCT07439484

Conditions

Clinical Stage I Esophageal Adenocarcinoma American Joint Committee on Cancer (AJCC) v8

Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8

Clinical Stage I Gastric Cancer AJCC v8

Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Clinical Stage II Esophageal Adenocarcinoma AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Actigraphy

Biospecimen Collection

Educational Intervention

Educational Intervention

Electronic Health Record Review

Study Details

Brief summary:

This clinical trial tests an individually tailored, supervised, remote exercise intervention to improve physical function for stage I-III gastroesophageal cancer survivors. Modern treatments for gastroesophageal cancer are effective at treating the cancer but are often aggressive, can be difficult for patients to tolerate, and can lead to significant debilitation and a loss of independence. Exercise is one promising intervention that could improve physical function in patients with gastroesophageal cancer after finishing systemic treatment. Home based exercise interventions in patients with cancer during and after chemotherapy can improve fatigue and function. An individually tailored, supervised, remote exercise intervention may improve physical function for stage I-III gastroesophageal cancer survivors.

Conditions

Clinical Stage I Esophageal Adenocarcinoma American Joint Committee on Cancer (AJCC) v8

Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8

Clinical Stage I Gastric Cancer AJCC v8

Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Clinical Stage II Esophageal Adenocarcinoma AJCC v8

Study ID

NCT07439484

Start date

Sep 11, 2026

Status verified date

Nov, 2026

Completion date

Sep 1, 2028

Anticipated

Primary completion date

Sep 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults ≥ 18 years old at the start of study treatment
  • Diagnosis of early-stage (Stage I, II, III) esophageal, gastroesophageal junction, or gastric cancer. Histology can be adenocarcinoma, squamous cell carcinoma, or poorly differentiated carcinoma
  • Treated with at least one systemic therapy (chemotherapy or immunotherapy) and within 12 months of completing curative intent gastroesophageal cancer (GEC) treatment
  • Have evidence of physical function impairment, defined as a SPPB score of < 12) at baseline
  • Ability to understand English and the willingness to sign a written informed consent document

Exclusion Criteria:

  • Patients with stage I disease who underwent endoscopic resection or surgery alone without perioperative systemic therapy
  • Patients with stage IV disease or unresectable locally advanced disease taking a palliative treatment approach without a clearly defined end of treatment
  • Patients currently receiving ongoing systemic therapy for GEC or another malignancy
  • Patients who are unable to provide informed consent
  • Any other condition or pre-existing co-morbidity that would, in the Investigator's judgment, contraindicate the participation in the study due to safety concerns with study procedures
  • Currently participating in another exercise intervention research study seeking to improve functional status, alleviate frailty, muscle strength, exhaustion/fatigue, or cognitive function

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Supportive care (Remote exercise intervention)

Patients receive access to the Moterum application and complete remotely delivered, supervised exercise sessions, over 1 hour, 3 times per week for 8 weeks. Sessions consist of both aerobic and resistance training exercises. Patients also receive written instructions and videos of strengthening exercises. Patients undergo blood sample collection throughout the study.

Interventions

Actigraphy

Ancillary studies

Biospecimen Collection

Undergo blood sample collection

Educational Intervention

Receive written instructions

Educational Intervention

Receive videos of strengthening exercises

Electronic Health Record Review

Ancillary studies

Exercise Intervention

Compete exercise sessions

Internet-Based Intervention

Receive access to Moterum application

Physical Performance Testing

Ancillary studies

Survey Administration

Ancillary studies

Primary outcome measure

  • Percentage of participants who attend at least 80% of the exercise sessions and complete the post-intervention functional assessment [ Time Frame: At 8 weeks ]

Central Contacts and Locations

Central contacts

Jingran Ji, MD

310-829-5471jingranji@mednet.ucla.edu

Locations

UCLA / Jonsson Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90095

Contacts

Jingran Ji, MD

310-829-5471jingranji@mednet.ucla.edu

Principal Investigator:

Jingran Ji, MD

More Information

Sponsor

Jonsson Comprehensive Cancer Center

Last update posted

Nov 5, 2026

Last verified

Nov, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-06. This information was provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center on 2026-11-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.