Recruiting

Heart Failure

Sponsor:

University Health Network, Toronto

Code:

NCT07447908

Conditions

Heart Failure

Heart Failure - NYHA II - IV

Heart Failure Patients

Cardiopulmonary Exercise Test

Apple Watch

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF. This multicentre study will validate whether aggregate biometric data from the Apple Watch combined with demographic, cardiac, and biomarker testing can improve our ability to predict heart failure outcomes among a diverse outpatient HF population.

Conditions

Heart Failure

Heart Failure - NYHA II - IV

Heart Failure Patients

Cardiopulmonary Exercise Test

Apple Watch

Study ID

NCT07447908

Start date

Jun 16, 2026

Status verified date

Jul, 2026

Completion date

Sep, 2029

Anticipated

Primary completion date

Sep, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • broad age range (> 18 years of age)
  • NT-proBNP > 400 or 1000 if in AF
  • Within 3 months post discharge from HF hospitalization/ HF ED visit/ HF rapid clinic visit with intensification of diuretic therapy
  • NYHA functional class I-IV, heart failure with reduced and preserved ejection fraction
  • Literacy in English
  • Patient provided informed consent

Exclusion Criteria:

  • Unable to perform a CPET based on the standard protocol
  • End stage renal disease requiring dialysis
  • Living with LVAD
  • MRP deems patient unfit for the study
  • Post heart transplant

Study Design

Enrollment

360 participants

Anticipated

Interventions and Outcome Measures

Arms

UHN Patients

Heart failure patients followed at UHN

Southlake Health Patients

Heart failure patients followed at Southlake Health

Sunnybrook Patients

Heart failure patients followed at Sunnybrook

Peterborough Regional Health Center Patients

Heart failure patients followed at Peterborough Regional Health Center

Primary outcome measure

  • Prediction of Cardiopulmonary Exercise Test Parameters [ Time Frame: 7 months ]
  • Prediction of worsening heart failure [ Time Frame: 7 months ]

Central Contacts and Locations

Central contacts

Ryan Li, MASc

6479669330ryan.li@uhn.ca

Ben Kim, PhD

ben.kim@uhn.ca

Locations

200 Elizabeth Street

Recruiting

Toronto, Ontario, Canada, M5G 2C4

Contacts

Ryan Li, MASc

+16479669330ryan.li@uhn.ca

Ben Kim, PhD

ben.kim@uhn.ca

Principal Investigator:

Yasbanoo Moayedi, MD

More Information

Sponsor

University Health Network, Toronto

Last update posted

Jul 6, 2026

Last verified

Jul, 2026

Keywords

  • Apple Watch
  • CPET
  • Heart Failure
  • Artificial Intelligence
  • Wearable Technology
  • Wearable
  • Remote monitoring

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-07-06.