Recruiting

Exercise

Sponsor:

University of Hartford

Code:

NCT07453550

Conditions

Hypertension (HTN)

Pre Hypertension

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

wall-squat

wall-squat-tradition

Study Details

Brief summary:

High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.

Conditions

Hypertension (HTN)

Pre Hypertension

Study ID

NCT07453550

Start date

Feb 1, 2026

Status verified date

Feb, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-55 yrs.
  • 24 hour average BP >110/70 mmHg, but < 160 systolic blood pressure
  • Able to provide informed consent

Exclusion Criteria:

  • Currently taking anti-hypertensive medication smokers and alcohol drinkers Inability to undertake exercise intervention (resistance and isometric exercise)

Current medical history of any of the following:

hyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel

Previous medication history of any of the following:

hyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel

Study Design

Enrollment

45 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

no intervention: Non-Ex control group

active comparator: Clustered Ex Condition

experimental: Scattered Ex Condition

Interventions

wall-squat

the experimental group will complete the four sets of wall-squats at four different times across the day: morning, noon, afternoon, night.

wall-squat-tradition

The other exercise group will do 4 sets of wall squat in a continuous way.

Primary outcome measure

  • 24 h blood pressure [ Time Frame: From the enrollment to the end of the study at six weeks ]

Central Contacts and Locations

Central contacts

Jinghui Yang, PT, MPT, PhD

347-429-0843jiyang@hartford.edu

Locations

University of Hartford

Recruiting

West Hartford, Connecticut, United States, 06117

Contacts

Jinghui Yang

3474290843jiyang@hartford.edu

More Information

Sponsor

University of Hartford

Last update posted

May 1, 2026

Last verified

Feb, 2026

Keywords

  • isometric exericse

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Hartford on 2026-05-01.