Recruiting

e-Align

Sponsor:

Johns Hopkins University

Code:

NCT07454824

Conditions

Dementia

Potentially Inappropriate Medication Use

Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Interventions

e-ALIGN Patient-Portal Deprescribing

Study Details

Brief summary:

The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.

Conditions

Dementia

Potentially Inappropriate Medication Use

Mild Cognitive Impairment (MCI)

Study ID

NCT07454824

Start date

Apr 15, 2026

Status verified date

Jun, 2026

Completion date

Feb 6, 2027

Anticipated

Primary completion date

Feb 6, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Patients: Age ≥65, with a diagnosis of MCI or dementia based on ICD-10 codes and ≥1 active CNS-PIM, who are active patient portal users.

Care partners:

  • Family or other companions >21 years who regularly help the patient with managing medications.

Exclusion Criteria:

  • As the trial will be based in primary care, individuals residing in long term care facilities or enrolled in hospice will be excluded.

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Patient Portal Deprescribing Intervention

e-ALIGN will be piloted via the patient portal. The intervention will provide patients and care partners with an educational video on the risks of Central Nervous System-Potentially Inappropriate Medications (CNS-PIM) through the patient portal, MyChart. It will also offer the participant the opportunity to discuss deprescribing options with the patient's primary care physician (PCP) or to receive a referral to discuss deprescribing options with a clinical pharmacist who is embedded in the primary care practice.

Patients who meet with the pharmacist will have two visits (intervention and follow-up). Patients who do not meet with a pharmacist will have a routine visit with the patient's PCP. Each participant will be on study (intervention period and additional follow-up) for approximately 3 months.

Interventions

e-ALIGN Patient-Portal Deprescribing

The intervention will consist of educational materials about deprescribing, which will be sent to the patient prior to the scheduled primary care visit.

Primary outcome measure

  • Number of patients who open the patient portal message [ Time Frame: 1 month after sending message ]
  • Number of patients who watch the video [ Time Frame: 1 month after sending message ]
  • Acceptability of educational video assessed by survey [ Time Frame: 1 month after sending message ]

Central Contacts and Locations

Central contacts

Ariel Green, MD, MPH, PhD

410-550-6733ariel@jhmi.edu

Locations

Johns Hopkins Community Physicians

Recruiting

Baltimore, Maryland, United States, 21209

Contacts

410-550-6733ariel@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Jun 16, 2026

Last verified

Jun, 2026

Keywords

  • deprescribing
  • polypharmacy
  • potentially inappropriate medications
  • dementia
  • cognitive impairment

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-06-16.