Recruiting

Menstrual Cycle Triglycerides

Sponsor:

University of Ottawa

Code:

NCT07459465

Conditions

Healthy Adult Females

Eligibility Criteria

Sex: Female

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Early Follicular Phase

Mid-Luteal Phase

Study Details

Brief summary:

The goal of this clinical trial is to investigate the effect of menstrual cycle phases on postprandial triglyceride concentrations in healthy young female adults. The main question it aims to answer is: do postprandial triglyceride concentrations differ between the follicular and luteal phases of the menstrual cycle?

Participants will: visit the laboratory for a preliminary screening session to assess eligibility, and undergo two experimental sessions consisting of six hours of seated rest following the consumption of a high-fat meal (one session conducted in the early follicular phase, and one session conducted in the mid-luteal phase of the menstrual cycle).

Conditions

Healthy Adult Females

Study ID

NCT07459465

Start date

Mar 26, 2026

Status verified date

Apr, 2026

Completion date

Aug 31, 2026

Anticipated

Primary completion date

Aug 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

  • English or French speaking
  • Ability to provide informed consent

Exclusion Criteria:

  • History or evidence of chronic disease
  • Current use of hypolipemic medication
  • Current use of hormonal contraceptives
  • Current use of antidepressants
  • Current use of anticoagulants
  • Ongoing smoking status
  • Experiencing pregnancy, puerperium, or irregular menstrual cycles

Study Design

Enrollment

12 participants

Anticipated

Allocation

Non randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Early Follicular Phase

experimental: Mid-Luteal Phase

Interventions

Early Follicular Phase

In the early follicular phase of the menstrual cycle, participants will undergo 6 hours of seated rest after the consumption of a high-fat meal representing 33% of estimated daily energy expenditure and consisting of 59% of calories from fat.

Mid-Luteal Phase

In the mid-luteal phase of the menstrual cycle, participants will undergo 6 hours of seated rest after the consumption of a high-fat meal representing 33% of estimated daily energy expenditure and consisting of 59% of calories from fat.

Primary outcome measure

  • Change from baseline in plasma total triglyceride concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma buoyant triglyceride concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma denser triglyceride concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma non-esterified fatty acid concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma insulin concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma glucose concentrations [ Time Frame: 6 hours ]
  • Change from baseline in plasma β-hydroxybutyrate concentrations [ Time Frame: 6 hours ]

Central Contacts and Locations

Central contacts

Pascal Imbeault, PhD

6135625800 ext 7290imbeault@uottawa.ca

Locations

Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa

Recruiting

Ottawa, Ontario, Canada, K1S 5S9

Contacts

Pascal Imbeault

16135625800imbeault@uottawa.ca

More Information

Sponsor

University of Ottawa

Last update posted

May 19, 2026

Last verified

Apr, 2026

Keywords

  • Triglyceride
  • Postprandial Lipemia
  • High-Fat Meal
  • Menstrual Cycle

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Ottawa on 2026-05-19.