Recruiting

Observational Study

Sponsor:

Ohio State University

Code:

NCT07468929

Conditions

Periodontal Disease

Periodontal Surgery

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Interventions

Blood samples for inflammatory markers

periodontal surgery

Periodontal maintenance

Non-surgical deep cleaning

Study Details

Brief summary:

The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:

  • How do the levels of inflammatory molecules in the blood change during a periodontal surgery?
  • How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure?
  • Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.

Conditions

Periodontal Disease

Periodontal Surgery

Study ID

NCT07468929

Start date

Jul 13, 2026

Status verified date

Aug, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 21-75 years of age
  • Systemically healthy
  • Non-smoker
  • scheduled to receive nonsurgical or surgical periodontal treatment under IV sedation

Exclusion Criteria:

  • Patients who have localized form of the disease (less than 30% of available tooth/implant sites are affected with the disease)
  • Non-english speaking individuals since informed consent form will be in English only.
  • Patients with uncontrolled systemic diseases (such as metabolic diseases, obesity, diabetes, high blood pressure) since these types of chronic inflammatory challenges would cause increase levels of circulatory serum pro-inflammatory markers.
  • Pregnant patients (pregnancy will be reported by the patient) since pregnancy itself would affect circulatory serum pro-inflammatory markers.
  • Patients who are not willing to have blood drawing for the study purpose.
  • Patients who are not willing to sign research related consent form.

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Arms

Control group 1

Recruited from patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning).

Control group 2

Recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia)

Surgical group

Recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.

Interventions

Blood samples for inflammatory markers

Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.

periodontal surgery

Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs

Periodontal maintenance

Regular cleaning to maintain health after surgical treatment for periodontal disease

Non-surgical deep cleaning

Debridement under local anesthesia, as based on treatment needs

Primary outcome measure

  • Serum CRP concentration (pg/ml) [ Time Frame: Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends; ]
  • Seum IL-1 concentration (pg/ml) [ Time Frame: During dental procedure intervention ]
  • Serum TNF concentration (pg/ml) [ Time Frame: Blood samples will be obtained immediately before, during and immediately after dental procedure intervention. ]

Central Contacts and Locations

Locations

The Ohio State University Graduate Periodontics Clinic

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Binnaz Leblebicioglu, DDS, MS, PhD

614-292-0371leblebicioglu.1@osu.edu

More Information

Sponsor

Ohio State University

Last update posted

Sep 11, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-12. This information was provided to ClinicalTrials.gov by Ohio State University on 2026-09-11.