Recruiting

Observational Study

Sponsor:

University of Kansas Medical Center

Code:

NCT07472088

Conditions

Knee Osteoarthritis

Patellofemoral Pain (PFPS)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

WBCT

Study Details

Brief summary:

Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called "runner's knee". It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stairs, or kneeling painful.

Symptomatic knee osteoarthritis (OA) is a common, long-term condition where the protective cartilage in the knee joint wears away, causing the bones to rub together, leading to daily pain and stiffness. In simple terms, it is a "wear-and-tear" disease of the entire joint that makes walking, climbing stairs, or bending the knee difficult.

The PFJ is where the patella (kneecap) meets the femoral trochlea (front part of the lower thigh bone) at the front of the knee. Patellar tracking refers to the movement of the patella that begins to engage in the distal femoral trochlear groove (smooth, U-shaped groove at the bottom of the thigh bone).

By doing this study, we hope to advance clinical knowledge of the PTJ features in a more natural position by using weight-bearing computed tomography (WBCT) images while the leg is straight and slightly bent. Determining links between specific knee symptoms and the PTJ structure on WBCT images could enable providers to effectively target the underlying causes and to develop targeted treatments.

Conditions

Knee Osteoarthritis

Patellofemoral Pain (PFPS)

Study ID

NCT07472088

Start date

Apr 29, 2026

Status verified date

May, 2026

Completion date

Aug, 2026

Anticipated

Primary completion date

Aug, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18
  • Knee pain, falling into either of the two groups, i.e., PFJ pain (pain only in the anterior region of the knee) or symptomatic knee OA (pain in any other area of the knee, including the anterior region)

Exclusion Criteria:

  • Bilateral total knee arthroplasty
  • Pregnant
  • Unable to stand safely for 2 minutes with support
  • Any condition that the investigator identifies as inappropriate for participation (e.g., unable to participant in consent process, unsafe to stand on WBCT platform, etc.)

Study Design

Enrollment

36 participants

Anticipated

Interventions and Outcome Measures

Arms

PFJ pain

Participants experiencing recurrent, atraumatic patella dislocation, knee pain isolated to the anterior region, or PFPS (pain around the patella, exacerbated by prolonged positioning or ascending/descending stairs)

Symptomatic knee OA

Participants experiencing pain in any other area of the knee, including the anterior region in combination with other regions

Interventions

WBCT

Images of the knee will be acquired using a WBCT, which provides a three-dimensional view of the patellofemoral joint in a loaded configuration.

Primary outcome measure

  • TT-TG [ Time Frame: From enrollment to end of study (1 day) ]
  • reTRF [ Time Frame: From enrollment to end of study (1 day) ]
  • Congruence Angle [ Time Frame: From enrollment to end of study (1 day) ]

Central Contacts and Locations

Central contacts

Yashaf Zaheer, MD

yzaheer@kumc.edu

Locations

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Yashaf Zaheer, MD

yzaheer@kumc.edu

Principal Investigator:

Neil A Segal, MD, MS

More Information

Sponsor

University of Kansas Medical Center

Last update posted

May 7, 2026

Last verified

May, 2026

Keywords

  • patellofemoral joint
  • knee osteoarthritis
  • weight-bearing CT (WBCT)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Kansas Medical Center on 2026-05-07.