Recruiting

Prehabilitation Program

Sponsor:

University of Massachusetts, Worcester

Code:

NCT07478185

Conditions

Pancreatic Cancer, Adult

Prehabilitation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Multimodal Prehabilitation

Study Details

Brief summary:

The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery. Prehabilitation is a program designed to improve a person's physical fitness, nutrition, and symptom control before surgery.

The study's main hypothesis is that patients with pancreatic cancer can take part in and adhere to a multimodal prehabilitation program during chemotherapy, and that doing so may improve physical function, patient experience, and early recovery after surgery.

Conditions

Pancreatic Cancer, Adult

Prehabilitation

Study ID

NCT07478185

Start date

Mar 31, 2026

Status verified date

Apr, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Feb, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18 years
  • Diagnosis of pancreatic ductal adenocarcinoma (PDAC)
  • Planned neoadjuvant chemotherapy prior to planned surgical resection
  • Medically stable and cleared to participate in physical activity/exercise programming
  • Able to provide informed consent
  • Ability to read, write and understand English

Exclusion Criteria:

  • Age <18 years
  • Pregnant
  • Prisoner
  • Severe cognitive impairment that precludes informed consent or participation
  • Contraindications to physical activity, including unstable cardiac disease, severe pulmonary disease, or recent myocardial infarction

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Multimodal Prehabilitation Program

Participants in this single-arm study will receive a structured prehabilitation program during neoadjuvant chemotherapy prior to planned pancreatic cancer surgery.

Interventions

Multimodal Prehabilitation

Participants will receive a structured, multimodal prehabilitation program delivered during neoadjuvant chemotherapy prior to planned pancreatic cancer surgery. The program integrates supervised, individualized exercise training, nutritional assessment and counseling with recommended preoperative immunonutrition, and supportive care focused on symptom management and functional support. Prehabilitation is delivered as an integrated component of preoperative care and continues through completion of neoadjuvant therapy until surgery.

Primary outcome measure

  • Feasibility of prehabilitation program delivery [ Time Frame: From enrollment through completion of neoadjuvant therapy (approximately 3-6 months) ]
  • Adherence to prehabilitation components [ Time Frame: From enrollment through preoperative assessment (approximately 3-6 months) ]

Central Contacts and Locations

Central contacts

Kayla R Widdowson, MD

774-641-1257kayla.widdowson@umassmed.edu

James M Lindberg, MD

508-334-5220james.lindberg@umassmemorial.org

Locations

UMass Memorial Medical Center

Recruiting

Worester, Massachusetts, United States, 01655

Contacts

Kayla R Widdowson, MD

774-641-1257kayla.widdowson@umassmed.edu

More Information

Sponsor

University of Massachusetts, Worcester

Last update posted

Apr 3, 2026

Last verified

Apr, 2026

Keywords

  • Prehabilitation
  • Nutritional status
  • Functional capacity
  • Pancreatic cancer
  • Pancreatectomy
  • Pancreaticoduodenectomy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Massachusetts, Worcester on 2026-04-03.