Recruiting

Ventilation Settings

Sponsor:

Laval University

Code:

NCT07484828

Conditions

Cardiac Arrest (CA)

Cardiogenic Shock

Mechanical Ventilation

Acid Base Disorder

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Initiation of mechanical ventilation

Study Details

Brief summary:

This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.

The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:

Determine how often acid-base disorders occur in these patients and describe their characteristics.

Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.

The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.

This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.

Participation does not involve any intervention, as the study uses existing medical records.

Conditions

Cardiac Arrest (CA)

Cardiogenic Shock

Mechanical Ventilation

Acid Base Disorder

Study ID

NCT07484828

Start date

Jun 9, 2026

Status verified date

Mar, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult (Age >=18 years old)
  • Under mechanical ventilation with endotracheal tube for :

post cardiac arrest or cardiogenic shock

\- Bood gases result availability up to 4 hours after coronary unit admission

Exclusion Criteria:

  • Lack of patient anthropometric data (height and weight) available in the patient record
  • No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
  • Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Patient post cardiac arrest

Patient with cardiogenic shock

Interventions

Initiation of mechanical ventilation

Blood gases evaluation after initiation of mechanical ventilation

Primary outcome measure

  • Acid-base disorder (respiratory acidosis) [ Time Frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample ]
  • Acid-base disorder (respiratory alcalosis) [ Time Frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample ]

Central Contacts and Locations

Central contacts

Francois Lellouche

1-418-656-8711francois.lellouche@criucpq.ulaval.ca

Locations

Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

Francois Lellouche Principal Investigator

418-656-8711francois.lellouche@criucpq.ulaval.ca

More Information

Sponsor

Laval University

Last update posted

Nov 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-06. This information was provided to ClinicalTrials.gov by Laval University on 2026-11-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.