Recruiting

Cancer Screening

Sponsor:

Inova Health Care Services

Code:

NCT07485322

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 35 - 70+

Healthy Volunteers: Accepted

Interventions

Avantect Multi-Cancer Detection Test

Nasal Swab

Study Details

Brief summary:

The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening regimen in veterans exposed to burn pits. The study results may describe the clinical and psychosocial impact such screening has on this potential population. The study hopes to share the premalignant and malignant findings identified and follow-up healthcare utilization associated with high-intensity cancer screening during the approximately 3-year study period (three annual screening assessments and an additional year of follow-up to determine participants' cancer status). The study will also explore the performance of new tools (nasal brush, multi-cancer detection blood test, and radiomic analysis) in detecting the development of cancer during the study period.

Conditions

Cancer

Study ID

NCT07485322

Start date

Jun 17, 2026

Status verified date

Jun, 2026

Completion date

Jul 31, 2029

Anticipated

Primary completion date

Apr 28, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 35 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • ≥ 35 years
  • Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for >1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).
  • Ability to understand and willing to sign informed consent
  • Ability to understand and willing to sign HIPAA Authorization

Exclusion Criteria:

  • No history of malignancy within the past 5 years (non-melanoma skin cancer and in situ carcinoma would still be eligible) and not currently being worked up clinically for suspicion of cancer.
  • For women of childbearing potential, not pregnant.

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Veterans exposed to burn pits

Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for >1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).

Interventions

Avantect Multi-Cancer Detection Test

Multi-cancer blood test to detect cancer DNA. Manufactured by ClearNote Health.

Nasal Swab

Two nasal brush swabs will be collected during the baseline screening period. The brushing of the inside of the nose is performed using a soft brush, with local anesthetic if necessary.

Primary outcome measure

  • STAI Questionnaire [ Time Frame: 3.5 years ]
  • Burn Pit Exposure Questionnaire [ Time Frame: 1 day ]
  • Cancer Outcomes Follow up Questionnaire [ Time Frame: 1 day ]
  • Intensive Cancer Screening Feasibility [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Bryan Bassig, PhD

(571) 472-3500bryan.bassig@inova.org

Salman Baig

(571) 472-3500salman.baig@inova.org

Locations

Inova Schar Cancer Institute

Recruiting

Fairfax, Virginia, United States, 22031

Contacts

Saville Research

571-472-3500Saville_Research@inova.org

Principal Investigator:

Rebecca Kaltman, MD

More Information

Sponsor

Inova Health Care Services

Last update posted

Jul 2, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Inova Health Care Services on 2026-07-02.