Recruiting
Phase 2

Fasted Exercise

Sponsor:

Arkansas Colleges of Health Education

Code:

NCT07487090

Conditions

Obesity

Exercise

Weight Loss

Eligibility Criteria

Sex: All

Age: 18 - 59

Healthy Volunteers: Accepted

Interventions

16 week exercise intervention

Study Details

Brief summary:

Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to treat or prevent heart disease / obesity is recommended, not all people respond well. Some see significant weight loss and health improvements while others see little changes. For these reasons, new strategies surrounding the use and design of an exercise program are needed. One such strategy could be performing aerobic exercise before breakfast (fasted exercise). When exercising fasted, food/energy stores are low, and one relies on stored body fat for energy. This may help heart health and weight loss. This has never been tested in a program long enough to see such changes. This study will, for the first time, assess the effects of a 16-week aerobic exercise program performed fasted compared to after eating. Outcomes will include blood fats, blood pressure, fat-burning abilities and weight loss.

Starting an exercise program can also make people to eat more. This limits the success of exercise. The study will also evaluate ways fasted exercise could change eating, as it possible that fasted exercise could also cause people to eat more, which would limit weight loss and health improvements.

Conditions

Obesity

Exercise

Weight Loss

Study ID

NCT07487090

Start date

Jan 5, 2026

Status verified date

Mar, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 59

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Aged 18-59
  • BMI 25-45
  • Healthy enough to exercise

Exclusion Criteria:

  • Taking medications or supplements that are known to influence energy expenditure,
  • Currently exercising more than once per week
  • Currently dieting for weight loss
  • Currently taking weight loss drugs
  • Have had a previous weight loss surgery
  • Currently diagnosed with Diabetes
  • Currently diagnosed with heart disease (Heart failure, uncontrolled hypertension, uncontrolled hypercholesterolemia, Coronary heart disease)

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Fasted group

Complete all exercise sessions of intervention before breakfast- fasted at least 8 hours

experimental: Fed exercise group

Complete all exercise sessions of intervention after breakfast- within 3 hours of eating at least 300 kcal

Interventions

16 week exercise intervention

Both groups will receive a 16-week supervised aerobic exercise program progressing to 1,600 kcal of EE per wk (4 sessions/week) at moderate intensity (40-50% heart rate reserve, HRR).

Primary outcome measure

  • body composition [ Time Frame: Baseline (week 0) and post-intervention (week 25) ]

Central Contacts and Locations

Locations

Arkansas Colleges of Health Education Research Institure Health and Wellness Center

Recruiting

Fort Smith, Arkansas, United States, 72916

Contacts

More Information

Sponsor

Arkansas Colleges of Health Education

Last update posted

Mar 23, 2026

Last verified

Mar, 2026

Keywords

  • Exercise
  • weight loss
  • obesity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-05. This information was provided to ClinicalTrials.gov by Arkansas Colleges of Health Education on 2026-03-23.