Recruiting

Virtual Reality

Sponsor:

Indiana University

Code:

NCT07496255

Conditions

Intensive Care Unit Delirium

Intensive Care Acquired Cognitive Impairment

Post Intensive Care Unit Syndrome

Virtual Reality Cognitive Training

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

VR-based cognitive training program

VR-based attention control

Study Details

Brief summary:

The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors. The VR program will be used at home through a headset and hand controls.

Conditions

Intensive Care Unit Delirium

Intensive Care Acquired Cognitive Impairment

Post Intensive Care Unit Syndrome

Virtual Reality Cognitive Training

Study ID

NCT07496255

Start date

Mar 19, 2026

Status verified date

Apr, 2026

Completion date

Jul 15, 2027

Anticipated

Primary completion date

Feb 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults aged 50 years or older
  • English speaking
  • Admitted to the intensive care unit (ICU) with acute respiratory failure/invasive mechanical ventilation
  • Screening positive for delirium (using Richmond Agitation Sedation Scale and Confusion Assessment Method for the ICU)

Exclusion Criteria:

  • Acute neurologic injury such as stroke, traumatic brain injury, brain mass, intracranial hemorrhage, seizures, or central nervous system infection
  • Chronic cognitive or physical function deficit preventing participation in study interventions or assessments (determined by chart diagnoses and direct participant interview)
  • Chronic cognitive impairment (including mild cognitive impairment or dementia) identified by chart diagnosis, prescription of anti-dementia medications, or Informant Questionnaire on Cognitive Decline in the Elderly Score (IQCODE) >3.3 obtained from family caregiver
  • Severe, uncorrected vision or hearing impairment preventing participation in intervention or outcomes assessments
  • Admitted with acute alcohol or drug intoxication or withdrawal
  • Severe, uncontrolled psychiatric disorder (bipolar disorder or schizophrenia)
  • History of severe vertigo, motion-induced sickness, headaches, light sensitivity, seizures, or prior intolerance of virtual reality (VR)
  • Receiving comfort care measures or not expected to survive the hospitalization
  • Prisoners or patients unable to provide consent
  • Not expected to be discharged home from the hospital, or living more than 50 miles from the nearest recruitment site, or homeless

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: VR-based cognitive training program

placebo comparator: VR-based attention control

Interventions

VR-based cognitive training program

VR-Cog features HomeTown Bound, a suite of 18 modules organized into four training categories: attention, processing speed, memory, and visuospatial.

VR-based attention control

VR-AC consists of a library of 9 nature scenes (content provided by Nature Treks VR).

Primary outcome measure

  • Measure the feasibility of VR-Cog in older adult ICU delirium survivors [ Time Frame: Feasibility will be measured at 4 weeks (the end of the intervention period) ]
  • Measure the acceptability of VR-Cog in older adult ICU delirium survivors [ Time Frame: Acceptability will be measured at 4 weeks (the end of the intervention period) ]
  • Measure the adherence to VR-Cog in older adult ICU delirium survivors [ Time Frame: Adherence will be measured at 4 weeks (the end of the intervention period) ]

Central Contacts and Locations

Central contacts

Sikandar Khan, DO, MS

(317) 274-9427sikhan@iu.edu

Lori Rawlings, RN, BSN

317-274-9052rawlingl@regenstrief.org

Locations

IU Health Methodist Hospital

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Sikandar Khan, DO, MS

317-274-9424sikhan@iu.edu

More Information

Sponsor

Indiana University

Last update posted

Apr 17, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Indiana University on 2026-04-17.