Recruiting

Pilates

Sponsor:

University of Illinois at Chicago

Code:

NCT07504120

Conditions

Multiple Sclerosis

Pilates Exercise

Walking

Balance

Fatigue in Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Pilates

Study Details

Brief summary:

Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.

Objective 2: To examine the impact of a 16-week remotely delivered Pilates intervention on depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

Aim Aim 1: To assess whether the 16-week remotely delivered Pilates intervention significantly improves walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS Aim 2: To investigate whether the 16-week remotely delivered Pilates intervention significantly improves depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

Hypothesis Hypothesis 1: The 16-week remotely delivered Pilates intervention will significantly improve walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.

Hypothesis 2: Participants receiving the 16-week remotely delivered Pilates intervention will demonstrate significantly greater improvements in depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

Conditions

Multiple Sclerosis

Pilates Exercise

Walking

Balance

Fatigue in Multiple Sclerosis

Study ID

NCT07504120

Start date

Nov 1, 2025

Status verified date

Oct, 2026

Completion date

Dec 1, 2027

Anticipated

Primary completion date

Dec 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Self-reported diagnosis of multiple sclerosis by a neurologist
  • Relapse-free for the past 30 days before screening
  • Able to speak and read English as the primary language
  • Access to the internet and e-mail,
  • Ability to use Zoom, and willingness to complete testing sessions and questionnaires
  • Ambulatory without an assistive device (for example, cane)
  • Low to moderate disability, defined as a score of 0-4 on the Patient-Determined Disease Steps (PDDS)
  • Insufficiently active, defined as a score < 14 on the Godin Leisure-Time Exercise Questionnaire-Health Contribution Score (GLTEQ-HCS)
  • Adequate visual ability and literacy to read materials printed in 14-point font
  • Currently treated with a disease-modifying therapy

Exclusion Criteria:

  • Pregnant
  • Elevated risk for strenuous or maximal exercise, defined as more than one "Yes" response on the Physical Activity Readiness Questionnaire (PAR-Q) during screening

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Pilates group

Behavioral: Pilates group

no intervention: Control group

Waitlist Group

Interventions

Pilates

REMOTLY PILATES EXERCISE

Primary outcome measure

  • Change from baseline in walking endurance (Six-Minute Walk Test distance) [ Time Frame: Baseline and 16 weeks (end of treatment) ]
  • Change from baseline in walking speed (Timed 25-Foot Walk) [ Time Frame: Baseline and 16 weeks (end of treatment) ]
  • Change from baseline in balance (Berg Balance Scale) [ Time Frame: Baseline and 16 weeks (end of treatment) ]
  • Change from baseline in fatigue (Fatigue Severity Scale) [ Time Frame: Baseline and 16 weeks (end of treatment) ]
  • Change from baseline in pain (Short-form McGill Pain Questionnaire) [ Time Frame: Baseline and 16 weeks (end of treatment) ]

Central Contacts and Locations

Locations

University of Illinois Chicago

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Parisa Najafi, PhD

7735055923pems@uic.edu

More Information

Sponsor

University of Illinois at Chicago

Last update posted

Oct 6, 2026

Last verified

Oct, 2026

Keywords

  • multiple sclerosis
  • Pilates
  • Fatigue
  • Cognition
  • Quality of life
  • Walking
  • Depression
  • Balance
  • Pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-07. This information was provided to ClinicalTrials.gov by University of Illinois at Chicago on 2026-10-06. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.