Recruiting

Aerobic & Resistance Exercise

Sponsor:

Mayo Clinic

Code:

NCT07526766

Conditions

Fibromuscular Dysplasia

Spontaneous Coronary Artery Dissection

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Not accepted

Interventions

Aerobic and resistance exercises

Study Details

Brief summary:

The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD).

Conditions

Fibromuscular Dysplasia

Spontaneous Coronary Artery Dissection

Study ID

NCT07526766

Start date

Sep 11, 2026

Status verified date

Sep, 2026

Completion date

Nov 1, 2027

Anticipated

Primary completion date

Aug 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Not accepted

Inclusion criteria:

  • History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain.
  • Able to provide written informed consent

Exclusion criteria:

  • Individuals who are clinically obese (BMI ≥36) and/or who suffer from musculoskeletal or other conditions that would limit exercise participation.
  • Individuals who are deemed medically unstable
  • Participants who are unable to comply with study requirements.
  • Pregnancy

Study Design

Enrollment

28 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Aerobic and resistance exercise

Patients with a history of Spontaneous Coronary Artery Dissection and/or Fibromuscular Dysplasia will undergo three exercise tests.

Interventions

Aerobic and resistance exercises

Subjects will undergo three exercise tests, each separated by at least 48 hours:

  • Symptom-limited cardiopulmonary exercise test (CPET): Patients will cycle upright starting at 0W (3 min) before the workload is increased by 10-35W·min-1 in a ramp fashion (like cycling up a progressively steeper hill) until volitional exhaustion for the determination of V̇O2peak and Wpeak
  • Two-stage submaximal constant power exercise test: Following a 5-minute warm-up (10-20 W), participants will cycle in the moderate intensity domain for 25 minutes followed by 25 minutes in the heavy intensity domain.
  • Six different resistance exercises of varying intensities: Participants will perform three sets of six different resistance exercises: chest press; lateral raises; abdominal crunches; planks; leg press; weighted lunges

Primary outcome measure

  • Change in blood pressure in response to aerobic exercise [ Time Frame: Baseline, 5 minutes, 25 minutes, 50 minutes and 55 minutes ]
  • Dartmouth COOP Functional Assessment Chart score [ Time Frame: Baseline ]
  • Duke Activity Index Status (DASI) score [ Time Frame: Baseline ]
  • International Physical Activity Questionnaire Short Form (IPAQ-SF) score [ Time Frame: Baseline ]
  • Change in perceived exertion [ Time Frame: Baseline, 25 minutes, and 50 minutes ]
  • Change in blood lactate concentration [La-]b [ Time Frame: Baseline, 25 minutes, and 50 minutes ]

Central Contacts and Locations

Central contacts

Armia R. Habil, MD

904-953-0859habil.armia@mayo.edu

Locations

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224

Contacts

Armia R. Habil, MD

904-953-0859habil.armia@mayo.edu

Principal Investigator:

Elizabeth H. Dineen, DO

More Information

Sponsor

Mayo Clinic

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-09-08.