TMSrTMS for Postoperative Brain Tumor Patients

Inclusion Criteria:

1. Patients aged 22-65 years old who have undergone surgical resection for a brain tumor.
2. Patients undergoing any form of prior therapy, other than previous TMS therapy, will be considered.
3. Patients who present with sustained postoperative motor deficits at 1-2 weeks postoperatively as defined by the presence of British Medical Research Council (MRC) motor scores of 3/5 or less, or a sustained decrement by one point on the MRC score in the affected extremity.
4. Patients who present within three years of surgery with chronic, persistent motor-functional deficits will be included to demonstrate generalizability of safety and efficacy in neurosurgery patients with chronic deficits.
5. Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

1. Patients with any clinical history of seizures.
2. Patients with implanted devices (e.g., pacemakers, implanted stimulators, intracranial electrodes, cochlear implants).
3. Patients who have undergone a brain biopsy alone without resection.
4. Patients with postoperative cognitive deficits as defined by a Mini Mental State Examination score <26.
5. History of bipolar disorder.
6. Pregnant or breast-feeding individuals.
7. Active suicidal ideation or plan as assessed by the Columbia Suicide Severity Rating Scale.
8. History of moderate to severe heart disease.
9. History of other neurological conditions defined by structural cerebral damage (e.g., stroke, multiple sclerosis, other neurodegenerative diseases, meningoencephalitis)