Recruiting

Motor Activation

Sponsor:

Oregon Health and Science University

Code:

NCT07549529

Conditions

Mild Traumatic Brain Injury (mTBI)

Concussion, Mild Traumatic Brain Injury

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Motor Activation Physical Therapy for mTBI

Standard of Care Physical Therapy for mTBI

Study Details

Brief summary:

This work will address an important gap in physical therapy rehabilitation after concussion. Physical therapy usually focuses on how the brain processes sensory information such as inner ear and vision for balance rehabilitation, but our recent research shows that people with imbalance more often have a problem with how they can respond to imbalance (i.e., motor activation). While there are complex laboratory tools to test motor activation for balance, these tests are not practical for the clinic. The goal of this study is to create both an exercise intervention focused on motor activation after concussion and simple, but objective and instrumented (wearable sensors), clinical measures of motor activation. Objectives: This research study has three aims. 1) The investigators and study team will develop an exercise program to improve the problems with how one's body responds to imbalance (i.e., improve motor activation) after a concussion. The study team will use a Community Based Participatory Research (CBPR) approach by collaborating with a team of people with a broad range of experience related to concussion. The study team will form a Community Advisory Board (CAB) that will include patients who have had a concussion, healthcare professionals with expertise in concussion, and healthcare administrators. The CAB will contain people working in the military and civilians. 2) The investigators will compare our new motor-focused physical therapy intervention to the standard sensory focused balance intervention. The goal is to determine which intervention program is more effective in treating balance problems after a concussion. The investigators hypothesize that the motor-focused program will help patients more compared to the sensory program. 3) The investigators and study team will create and test several balance tests that can be used in the clinical without expensive research equipment to our standard research-based motor activation tests. This aim will allow the study team to determine if the clinical tests perform as well as the research-grade tests. To make the test useful to clinicians, the study team will use simpler technology like smart-phone applications, wearable sensors, and virtual reality goggles that are both affordable and practical for healthcare providers.

Conditions

Mild Traumatic Brain Injury (mTBI)

Concussion, Mild Traumatic Brain Injury

Study ID

NCT07549529

Start date

Jun 30, 2026

Status verified date

Sep, 2026

Completion date

Aug 30, 2029

Anticipated

Primary completion date

Aug 30, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed mTBI (concussion)
  • 18-60 years of age
  • More than 2 weeks from the date of the most recent mTBI
  • Less than 6 months from the most recent mTBI
  • Persisting symptoms from the mTBI

Exclusion Criteria:

  • Injury, medical, or neurological illness that could explain balance issues
  • Moderate to severe substance abuse in the past month
  • Display behavior that would interfere with safety during data collection
  • Significant pain during the study period (> 7/10)
  • Pregnancy
  • Persistent use of medications that cause balance impairment during the study
  • Active in physical therapy services for mTBI symptoms

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Participants with motor physical therapy for mTBI

Participants in this arm of the study will receive physical therapy focused on reactive and dynamic balance exercises to improve motor activation for stability.

active comparator: Standard of care physical therapy treatment for mTBI

This arm of the study will receive physical therapy in accordance with current clinical practice guidelines for mTBI treatment.

Interventions

Motor Activation Physical Therapy for mTBI

The motor activation program will complete approximately 12 rehabilitation sessions involving a novel physical therapy program with exercises targeted to improve dynamic and reactive balance.

Standard of Care Physical Therapy for mTBI

This arm of the study will complete approximately 12 rehabilitation sessions involving the the current clinical practice guidelines for mTBI treatment including exercises for aerobic tolerance, neck pain, balance, and movement.

Primary outcome measure

  • Instrumented, Modified Push & Release Test (I-mP&R) - Time to Stability [ Time Frame: Weeks 0 and 7 of study ]

Central Contacts and Locations

Central contacts

Locations

OHSU Balance Disorders Laboratory

Recruiting

Portland, Oregon, United States, 97239

Contacts

Laurie King, PhD, PT, MCR

503-418-2602kingla@ohsu.edu

Principal Investigator:

Laurie King, PhD, PT, MCR

University of Utah Neuromechanics and Applied Locomotion Laboratory

Recruiting

Salt Lake City, Utah, United States, 84106

Contacts

More Information

Sponsor

Oregon Health and Science University

Last update posted

Sep 24, 2026

Last verified

Sep, 2026

Keywords

  • mTBI
  • concussion
  • motor activation
  • reaction time
  • physical therapy
  • vestibular rehabilitation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2026-09-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.