Recruiting

Suction vs. Water Seal

Sponsor:

Vanderbilt University Medical Center

Code:

NCT07551791

Conditions

Hemothorax; Traumatic

Hemopneumothorax; Traumatic

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Suction

Water Seal

Study Details

Brief summary:

Traumatic pneumothorax and hemothorax are common consequences of chest injury, often requiring prompt tube thoracostomy to re-expand the lung and drain accumulated blood or air. Current practice varies widely regarding whether chest tubes should initially be placed to suction or to water seal, and prior studies have reported mixed findings. While suction may theoretically improve drainage and lung expansion, some studies suggest it may prolong air leaks and chest tube duration. Conversely, initial water seal has been associated with shorter tube duration without an increase in complications. The predecessor to this trial, the SEAL IT Trial, demonstrated that water seal reduced chest tube duration in patients with pneumothorax without an increase in complication, but excluded those with significant hemothorax. This single-center, randomized controlled trial (SUS-HPTX) will expand upon those findings by evaluating the effect of initial chest tube management strategy, suction versus water seal, in trauma patients with hemopneumothorax or hemothorax. Patients will be assigned to one of the two groups based on calendar month of enrollment, with clinicians able to adjust management as needed. The primary outcome is chest tube duration. Secondary outcomes include chest tube-related complications (e.g., empyema, pneumonia, re-accumulation of pneumothorax or hemothorax, need for additional procedures), hospital length of stay, readmissions, and mortality. Because both suction and water seal are accepted standards of care, the study involves minimal incremental risk. Findings will expand prior evidence and inform best practices for chest tube management in trauma

Conditions

Hemothorax; Traumatic

Hemopneumothorax; Traumatic

Study ID

NCT07551791

Start date

Apr 14, 2026

Status verified date

Apr, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Oct, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Admitted to trauma service
  • Patient has hemothorax or hemopneumothorax requiring chest tube

Exclusion Criteria:

  • Less than 18 years old, pregnant, prisoner, chest tube placed prior to CT scan

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Even months

experimental: Odd months

Interventions

Suction

Initial chest tube placed to suction

Water Seal

Initial chest tube placed to water seal

Primary outcome measure

  • Chest tube duration [ Time Frame: hours from placement of chest tube to removal of chest tube, on average 3 days ]

Central Contacts and Locations

Central contacts

Locations

Vanderbilt University Medical Center

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Jun 2, 2026

Last verified

Apr, 2026

Keywords

  • traumatic
  • hemothorax
  • hemopneumothorax
  • thoracostomy tube

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2026-06-02.