Recruiting

Observational Study

Sponsor:

Longevity Metrics, Inc.

Code:

NCT07563777

Conditions

Aging

Aging Well

All-Cause Mortality

Mortality

Metabolic Syndrome

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Comprehensive Multi-System Clinical Screening

Study Details

Brief summary:

The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.

Conditions

Aging

Aging Well

All-Cause Mortality

Mortality

Metabolic Syndrome

Study ID

NCT07563777

Start date

Feb 9, 2025

Status verified date

Jun, 2026

Completion date

Dec 31, 2099

Anticipated

Primary completion date

Dec 31, 2099

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18 years or older
  • Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative
  • Willing to participate in longitudinal follow-up

Exclusion Criteria:

  • Age under 18 years

Study Design

Enrollment

1000000 participants

Anticipated

Interventions and Outcome Measures

Interventions

Comprehensive Multi-System Clinical Screening

Comprehensive multi-system clinical screening battery including cardiopulmonary exercise testing, body composition assessment by DEXA, echocardiography, electrocardiography, spirometry, neurocognitive testing, sensory assessment, metabolic testing, physical examination, and detailed medical, social, occupational, and environmental history. Participants receive individualized clinical findings and investigational longevity constructs at the conclusion of screening.

Primary outcome measure

  • All-Cause Mortality [ Time Frame: From enrollment until death, assessed periodically, up to 100 years ]
  • Cause-Specific Mortality [ Time Frame: From enrollment until death, assessed periodically, up to 100 years ]

Central Contacts and Locations

Central contacts

William E Brandenburg, MD

3035010016info@longevitymetrics.org

Locations

Longevity Metrics

Recruiting

Boulder, Colorado, United States, 80301

Contacts

William E Brandenburg, MD

3035010016info@longevitymetrics.org

More Information

Sponsor

Longevity Metrics, Inc.

Last update posted

Jun 11, 2026

Last verified

Jun, 2026

Keywords

  • Longevity
  • Cardiopulmonary Exercise Testing
  • Body Composition
  • Preventive Medicine
  • Surrogate Endpoint Validation
  • Mortality Prediction
  • Functional Decline
  • Healthspan
  • Life Expectancy
  • Biological Aging
  • Preventive Screening
  • Longitudinal Cohort
  • Biomarker Validation
  • Human Performance
  • Population Health
  • Centenarian

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Longevity Metrics, Inc. on 2026-06-11.