Recruiting

Observational Study

Sponsor:

Indiana University

Code:

NCT07566611

Conditions

Idiopathic Bronchiectasis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Nasal Nitric Oxide Measurement

Nasopharyngeal (Nasal) Samples

Study Details

Brief summary:

The purpose of this study is to help determine how often primary ciliary dyskinesia (PCD) is present but undiagnosed in adults with bronchiectasis.

Conditions

Idiopathic Bronchiectasis

Study ID

NCT07566611

Start date

Jul 17, 2026

Status verified date

Aug, 2026

Completion date

Jan 31, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults (≥18) with CT-confirmed bronchiectasis

Exclusion Criteria:

  • Pre-existing diagnosis of cystic fibrosis
  • Pre-existing diagnosis of primary ciliary dyskinesia
  • Inability to perform testing
  • Refusal of consent

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Bronchiectasis

patients with a known or new diagnosis of bronchiectasis

Interventions

Nasal Nitric Oxide Measurement

Subjects will have their nasal nitric oxide measured using commercially available chemiluminescence analyzer in accordance with American Thoracic Society/European Respiratory Society guidelines

Nasopharyngeal (Nasal) Samples

Human nasal epithelial cells will be collected via nasal swab, nasal curettage or nasal brush from each nostril.

Primary outcome measure

  • Percentage of participants with a screen positive result [ Time Frame: From Baseline through study completion, approximately two years. ]

Central Contacts and Locations

Central contacts

Kenzie Mahan

3172748899krmahan@iu.edu

Lisa Bendy

(317) 278-7152lbendy@iu.edu

Locations

Riley Hospital for Children

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Kenzie Mahan

3172748899krmahan@iu.edu

More Information

Sponsor

Indiana University

Last update posted

Aug 12, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-17. This information was provided to ClinicalTrials.gov by Indiana University on 2026-08-12. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.