Recruiting

LiFT A vs. LiFT BA Novel Mobile Health Intervention for Improving Tobacco Cessation Among Young Adults

Sponsor:

Fred Hutchinson Cancer Center

Code:

NCT07571018

Conditions

Tobacco-Related Carcinoma

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Smartphone app-based Intervention

Communication intervention

Survey Administration

Study Details

Brief summary:

Tobacco use is the leading cause of preventable cancer deaths. Among young adults, approximately 1 in 5 use commercial nicotine and tobacco products, putting them at risk of developing nicotine addiction and long-term health effects from exposure to toxicants. Innovative approaches are needed to engage young adults in treatment, as they are less engaged in traditional treatment.

This clinical trial compares two versions of a mobile health intervention called Living Free from Tobacco (LiFT), designed to support nicotine and tobacco cessation among young adults. Both versions of the app are designed to motivate and support young adults to stop using nicotine and tobacco, regardless of current readiness to quit. Version A of the LiFT app (LiFT A) focuses on increasing psychological flexibility to support cessation, while Version B (LiFT B) provides educational content and resources related to tobacco use and cessation. Both versions of the program are delivered through a smartphone application and include accompanying text messages.

Conditions

Tobacco-Related Carcinoma

Study ID

NCT07571018

Start date

Jun 7, 2026

Status verified date

Jun, 2026

Completion date

Apr 1, 2028

Anticipated

Primary completion date

Apr 1, 2028

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-identify being between 18 and 30 years of age
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be a United States (US) resident, with a US mailing address
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must own a smartphone
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report having internet access for the interviews
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are interested in participating in the study for themselves (versus \[vs\] someone else)
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they understand and agree to the conditions of compensation
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are not currently incarcerated
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be willing and able to complete study procedures in English
PILOT TRIAL: Participants must self-identify being between 18 and 30 years of age
PILOT TRIAL: Participants must currently reside in the US and anticipate continued residence for the duration of the study (3 months)
PILOT TRIAL: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
PILOT TRIAL: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
PILOT TRIAL: Participants must self-report having at least weekly internet access for the next three months
PILOT TRIAL: Participants must be willing and able to download an app to their phone and receive text messages
PILOT TRIAL: Participants must self-report current use of a personal email account
PILOT TRIAL: Participants must self-report current use of text messaging
PILOT TRIAL: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)
PILOT TRIAL: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
PILOT TRIAL: Participants must self-report that they understand and agree to the conditions of compensation
PILOT TRIAL: Participants must self-report that they are not currently incarcerated
PILOT TRIAL: Participants must be willing to use the assigned intervention program, complete the study assessments, and complete an online consent form in English
POST PILOT TRIAL DIARY STUDY: Participants must self-identify being between 18 and 30 years of age
POST PILOT TRIAL DIARY STUDY: Participants must currently reside in the US
POST PILOT TRIAL DIARY STUDY: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
POST PILOT TRIAL DIARY STUDY: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
POST PILOT TRIAL DIARY STUDY: Participants must self-report having at least internet access for the duration of the diary study
POST PILOT TRIAL DIARY STUDY: Participants must be willing and able to download an app to their phone and receive text messages
POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of a personal email account
POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of text messaging
POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)
POST PILOT TRIAL DIARY STUDY: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
POST PILOT TRIAL DIARY STUDY: Participants must self-report that they understand and agree to the conditions of compensation
POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are not currently incarcerated
POST PILOT TRIAL DIARY STUDY: Participants must be willing to use the intervention program, complete the study assessments, and complete an online consent form in English

Exclusion Criteria:

USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not be < 18 or > 30 years of age
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not have a Google voice number as their sole phone number
USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English
PILOT TRIAL: Participants must not be < 18 or > 30 years of age
PILOT TRIAL: Participants must not be currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (but initiating these treatments during the study is allowed)
PILOT TRIAL: Participants must not be a member of the same household as another research participant
PILOT TRIAL: Participants must not have a Google voice number as their sole phone number
PILOT TRIAL: Participants must not be identified as fraudulent per our fraud prevention protocol
PILOT TRIAL: Participants must not be pregnant or plan on becoming pregnant over the next 3 months
POST PILOT TRIAL DIARY STUDY: Individuals must not be < 18 or > 30 years of age
POST PILOT TRIAL DIARY STUDY: Participants must not have a Google voice number as their sole phone number
POST PILOT TRIAL DIARY STUDY: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English

Study Design

Enrollment

140 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

no intervention: User-centered design and program development phase (interview) [Objective 1]

Participants attend user testing interviews where they interact with LiFT app prototypes and provide feedback through think-aloud methods to support refinement of the intervention content and features.

experimental: Pilot phase, Arm I (LiFT A app, LiFT A text messages) [Objective 2]

Participants use the LiFT A app, which includes interactive games and exercises, educational content, and tools tailored to young adults using an ACT treatment approach, for 3 months. Participants also receive LiFT A text messages 2-3 times per week.

experimental: Pilot phase, Arm II (LiFT B app, LiFT B text messages) [Objective 2]

Participants use the LiFT B app, which includes educational resources on preparing to quit, nicotine withdrawal, coping with withdrawal, mental health, along with health information videos, for 3 months. Participants also receive LiFT B text messages 2-3 times per week.

other: Post pilot trial diary study phase (LiFT, survey, interview) [Objective 3]

Participants use the LiFT app and complete daily usability and satisfaction assessments for approximately 1 week. Participants also complete a survey and attend an interview.

Interventions

Smartphone app-based Intervention

Use LiFT A app

Smartphone app-based Intervention

Use LiFT B app

Communication intervention

Receive LiFT A text messages

Communication intervention

Receive LiFT B text messages

Survey Administration

Complete surveys

Interview

Attend interview

Assessment

Complete usability assessment

Survey Administration

Complete survey

Primary outcome measure

Overall satisfaction (Pilot trial phase) [ Time Frame: At 3 months ]
Number of logins to assigned application (Pilot trial phase) [ Time Frame: At 3 months ]
Usefulness of the program (Pilot trial phase) [ Time Frame: At 3 months ]
Usefulness of text messages (Pilot trial phase) [ Time Frame: At 3 months ]
Satisfaction with perceived tailoring (Pilot trial phase) [ Time Frame: At 3 months ]
Satisfaction with guidance on how to quit (Pilot trial phase) [ Time Frame: At 3 months ]
Perception that program offered a novel approach to quitting (Pilot trial phase) [ Time Frame: At 3 months ]
Perceived helpfulness for quit preparation (Pilot trial phase) [ Time Frame: At 3 months ]
Willingness to recommend program to a friend (Pilot trial phase) [ Time Frame: At 3 months ]
Usability (Post pilot trial diary study phase) [ Time Frame: At completion of post pilot trial diary study phase (At Day 9) ]

Central Contacts and Locations

Central contacts

Jaimee Heffner, PhD

206-667-7314 jheffner@fredhutch.org

Locations

New Mexico State University

Recruiting

Las Cruces, New Mexico, United States, 88003

Contacts

Tamara Stimatze, PhD

575-646-4106 tstimatz@nmsu.edu

Principal Investigator:

Tamara Stimatze, PhD

Fred Hutch/University of Washington Cancer Consortium

Recruiting

Seattle, Washington, United States, 98109

Contacts

Jaimee Heffner, PhD

206-667-7314 jheffner@fredhutch.org

Principal Investigator:

Jaimee Heffner, PhD

More Information

Sponsor

Fred Hutchinson Cancer Center

Last update posted

Sep 3, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-04. This information was provided to ClinicalTrials.gov by Fred Hutchinson Cancer Center on 2026-09-03.