Recruiting

Mindfulness-Based Cognitive TherapySingle Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

Sponsor:

University of Washington

Code:

NCT07573241

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MBCT

Study Details

Brief summary:

This observational study will examine what emotional, physical, and environmental factors make it easier or harder for people with multiple sclerosis (MS) and chronic pain to practice mindfulness daily while participating in a group-based Mindfulness-Based Cognitive Therapy (MBCT) program.

Conditions

Multiple Sclerosis

Study ID

NCT07573241

Start date

Jul 17, 2026

Status verified date

Jul, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Mar 31, 2028

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Have an MS diagnosis of any subtype per record review
Average pain intensity in past week of at least moderate severity (>3 on the 0-10 numerical rating scale)
Report pain >50% of days in the past 3 months.
Are able to comply with study procedures and complete measures independently via self-report (on mobile phone)

Exclusion Criteria:

Less than 18 years of age
Score greater than 8 on the Expanded Disability Status Scale
Have significant cognitive impairment as indicated by 1 or more errors on the 6-item Cognitive Screener
Change in disease modifying medications in the past 3 months assessed via self-report (although participants will be considered eligible after the 3-month window)
History of MS relapse within the last 30 days prior to screening assessed via self-report (although participants will be considered eligible after the 3-month window)
Current suicidal ideation with intent or plan as indicated by a score of 1 or higher on the Patient Health Questionnaire-9 suicide item and further assessment with the Columbia-Suicide Severity Rating Scale (although individuals with suicidal ideation but no intent or plan will be considered eligible)
Currently engaged in psychotherapy for pain assessed via self-report
Currently have a "regular" mindfulness practice defined as > 3 days per week assessed via self-report
Inability to read or speak English

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Mindfulness-Based Cognitive Therapy (MBCT)

Participants will attend eight, 2-hour group treatment MBCT sessions delivered using free video-conferencing technology. Groups will consist of 6-12 people who also have MS and chronic pain. Participants will be asked to practice skills learned in session between sessions. MBCT integrates mindfulness meditation practices within a CBT-oriented framework to address not only unhelpful pain cognitions and behaviors but also attentional control, decoupling of attention from emotion, mindful cognitions, and meditative behavior.

Interventions

MBCT

Primary outcome measure

Daily Mindfulness Practice [ Time Frame: Twice daily for approximately 10 weeks (1 week before, 8 weeks during, and 1 week after the MBCT program) ]

Central Contacts and Locations

Central contacts

Erin G Mistretta, PhD

206-668-4168 emistr@uw.edu

Dawn Ehde, PhD

206-744-2811 edhe@uw.edu

Locations

University of Washington

Recruiting

Seattle, Washington, United States, 98104

Contacts

Erin G Mistretta, PhD

emistr@uw.edu

More Information

Sponsor

University of Washington

Last update posted

Jul 24, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Washington on 2026-07-24.